26 November 2024 : Clinical Research
Sarcopenia's Role in Neoadjuvant Chemotherapy Outcomes for Locally Advanced Breast Cancer: A Retrospective Analysis
Mustafa Karaca1ACDEF, Mustafa Serkan Alemdar2BDF, Özge Deniz Karaca3ABEF, Yıldız Kılar4BD, Gökhan Köker3BEF, Hasan Sözel5CDE, Mustafa Yıldız2DEF, Gülhan Özçelik Köker1DEF, Mustafa Özgür Arici
2BDEF*
DOI: 10.12659/MSM.945240
Med Sci Monit 2024; 30:e945240
Table 4 Comparison of treatment responses and recurrence by pre-treatment sarcopenia status.
| Pre-NAC sarcopenia | Absent | Present | P | |||
|---|---|---|---|---|---|---|
| n | % | n | % | |||
| Non-pCR | 97 | 57.1 | 36 | 64.3 | 0.341 | |
| pCR | 73 | 42.9 | 20 | 35.7 | ||
| 1 | 17 | 10.0 | 6 | 10.7 | 0.494 | |
| 2 | 29 | 17.1 | 12 | 21.4 | ||
| 3 | 38 | 22.4 | 10 | 17.9 | ||
| 4 | 13 | 7.6 | 8 | 14.3 | ||
| 5 | 73 | 42.9 | 20 | 35.7 | ||
| No response | 15 | 8.8 | 6 | 10.7 | 0.625 | |
| Partial response | 82 | 48.2 | 30 | 53.6 | ||
| Complete response | 73 | 42.9 | 20 | 35.7 | ||
| Absent | 15 | 8.8 | 6 | 10.7 | 0.673 | |
| Present | 155 | 91.2 | 50 | 89.3 | ||
| Progressive/stable disease | 11 | 6.6 | 3 | 5.6 | 0.159 | |
| Partial response | 110 | 66.3 | 43 | 79.6 | ||
| Complete response | 45 | 27.1 | 8 | 14.8 | ||
| Absent | 11 | 6.6 | 3 | 5.6 | 1.000* | |
| Present | 155 | 93.4 | 51 | 94.4 | ||
| Absent | 158 | 92.9 | 48 | 85.7 | 0.109* | |
| Present | 12 | 7.1 | 8 | 14.3 | ||
| Deceased | 5 | 2.9 | 3 | 5.4 | 0.413* | |
| Alive | 165 | 97.1 | 53 | 94.6 | ||
| NAC –neoadjuvant chemotherapy; pCR – pathologic complete response. * Fisher’s exact test. | ||||||