26 November 2024 : Clinical Research
Sarcopenia's Role in Neoadjuvant Chemotherapy Outcomes for Locally Advanced Breast Cancer: A Retrospective Analysis
Mustafa Karaca1ACDEF, Mustafa Serkan Alemdar2BDF, Özge Deniz Karaca3ABEF, Yıldız Kılar4BD, Gökhan Köker3BEF, Hasan Sözel5CDE, Mustafa Yıldız2DEF, Gülhan Özçelik Köker1DEF, Mustafa Özgür Arici
2BDEF*
DOI: 10.12659/MSM.945240
Med Sci Monit 2024; 30:e945240
Table 5 Comparison of treatment responses and recurrence by post-treatment sarcopenia status.
| Pre-NAC sarcopenia | Absent | Present | P | |||
|---|---|---|---|---|---|---|
| n | % | n | % | |||
| Non-pCR | 82 | 61.2 | 51 | 55.4 | 0.387 | |
| pCR | 52 | 38.8 | 41 | 44.6 | ||
| 1 | 13 | 9.7 | 8 | 8.7 | 0.073 | |
| 2 | 21 | 15.6 | 22 | 23.9 | ||
| 3 | 36 | 26.9 | 12 | 13.0 | ||
| 4 | 12 | 9.0 | 9 | 9.8 | ||
| 5 | 52 | 38.8 | 41 | 44.6 | ||
| No response | 13 | 9.7 | 8 | 8.7 | 0.688 | |
| Partial response | 69 | 51.5 | 43 | 46.7 | ||
| Complete response | 52 | 38.8 | 41 | 44.6 | ||
| Absent | 13 | 9.7 | 8 | 8.7 | 0.798 | |
| Present | 121 | 90.3 | 84 | 91.3 | ||
| Progressive/stable disease | 12 | 9.2 | 2 | 2.2 | 0.097 | |
| Partial response | 86 | 66.2 | 67 | 74.4 | ||
| Complete response | 32 | 24.6 | 21 | 23.3 | ||
| Absent | 12 | 9.2 | 2 | 2.2 | ||
| Present | 118 | 90.8 | 88 | 97.8 | ||
| Absent | 121 | 90.3 | 85 | 92.4 | 0.586 | |
| Present | 13 | 9.7 | 7 | 7.6 | ||
| Deceased | 5 | 3.7 | 3 | 3.3 | 1.000* | |
| Alive | 129 | 96.3 | 89 | 96.7 | ||
| NAC – neoadjuvant chemotherapy; pCR – pathologic complete response. values indicate statistical significance. * Fisher’s exact test. | ||||||