Sarcopenia's Role in Neoadjuvant Chemotherapy Outcomes for Locally Advanced Breast Cancer: A Retrospective Analysis

Mustafa Karaca; Mustafa Serkan Alemdar; Özge Deniz Karaca; Yıldız Kılar; Gökhan Köker; Hasan Sözel; Mustafa Yıldız; Gülhan Özçelik Köker; Mustafa Özgür Arici

doi:10.12659/MSM.945240

26 November 2024 : Clinical Research

Sarcopenia's Role in Neoadjuvant Chemotherapy Outcomes for Locally Advanced Breast Cancer: A Retrospective Analysis

Mustafa Karaca^1ACDEF, Mustafa Serkan Alemdar^2BDF, Özge Deniz Karaca^3ABEF, Yıldız Kılar^4BD, Gökhan Köker^3BEF, Hasan Sözel^5CDE, Mustafa Yıldız^2DEF, Gülhan Özçelik Köker^1DEF, Mustafa Özgür Arici

^2BDEF*

DOI: 10.12659/MSM.945240

Med Sci Monit 2024; 30:e945240

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Table 6 Comparison of treatment responses in non-sarcopenic patients.

Variables		Pre-NAC normal		Post-NAC normal		P
Variables		n	%	n	%	P
NAC response	Non-pCR	73	58.4	9	100.0	^*
NAC response	pCR	52	41.6	0	0.0	^*
Pathologic response	Absent	12	9.6	1	11.1	1.000^*
Pathologic response	Present	113	90.4	8	88.9	1.000^*
Radiologic response	Absent	10	8.3	2	22.2	0.195^*
Radiologic response	Present	111	91.7	7	77.8	0.195^*
Recurrence/progression	Absent	115	92.0	6	66.7	^*
Recurrence/progression	Present	10	8.0	3	33.3	^*
Latest status	Exitus	4	3.2	1	11.1	0.298^*
Latest status	Alive	121	96.8	8	88.9	0.298^*
NAC – neoadjuvant chemotherapy; pCR – pathologic complete response. values indicate statistical significance. ^* Fisher’s exact test.

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Sarcopenia's Role in Neoadjuvant Chemotherapy Outcomes for Locally Advanced Breast Cancer: A Retrospective Analysis

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