11 September 2024 : Clinical Research
Prognostic Significance of the Advanced Lung Cancer Inflammation Index in Metastatic Small Cell Lung Cancer: A Retrospective Analysis of 96 Patients
Muslih Ürün
1ABDEF, Gürkan Güner 2AEF*, Yasin Sezgin 1ABE, Emre Uysal 3CDE, Abdullah Sakin 4AE, Saadettin Kilickap 5AE
DOI: 10.12659/MSM.945752
Med Sci Monit 2024; 30:e945752
Table 1 Baseline characteristics and comparison by advanced lung cancer inflammation index (ALI) score.
| Characteristic | Total (n=96) | ALI <32.5 (n=61) | ALI ≥32.5 (n=35) | P |
|---|---|---|---|---|
| Age | 61 (41–82) | 62 (41–82) | 60 (42–77) | 0.766 |
| Sex | ||||
| Male | 84 (87.5) | 56 (91.8) | 28 (80) | 0.115 |
| Female | 12 (12.5) | 5 (8.2) | 7 (20) | |
| ECOG PS | ||||
| 0 | 23 (24) | 9 (14.8) | 14 (40) | |
| 1 | 43 (44.8) | 27 (44.3) | 16 (45.7) | |
| 2 | 30 (31.3) | 25 (41) | 5 (14.3) | |
| Height, cm | 170 (145–196) | 170 (146–185) | 170 (145–196) | 0.688 |
| Weight, kg | 69 (45–130) | 64 (45–90) | 74 (60–130) | |
| BMI, kg/m | 24.2 (16.9–42.5) | 22.8 (16.9–30.9) | 26.4 (21.1–42.5) | |
| Albumin, g/dL | 3.8 (2.7–4.9) | 3.7 (2.7–4.7) | 4.3 (2.7–4.9) | |
| Neutrophil, cell/mm×10 | 5.9 (1.4–14.4) | 6.7 (2.5–14.4) | 4.7 (1.4–8.9) | |
| Lymphocyte, cell/mm×10 | 1.7 (0.3–4.1) | 1.5 (0.3–2.7) | 2.2 (0.9–4.1) | |
| Monocyte, cell/mm×10 | 0.7 (0.1–2.3) | 0.7 (0.1–2.3) | 0.7 (0.2–1.3) | 0.302 |
| Platelet, cell/mm×10 | 281.5 | 278 (135–581) | 286 (100–656) | 0.752 |
| NLR | 3.4 (0.5–21.9) | 5 (2.3–21.9) | 2.1 (0.5–3.3) | |
| LMR | 2.3 (0.8–18.6) | 1.9 (0.8–18.6) | 3.9 (1.9–12.4) | |
| PLR | 172 (50.3–868) | 236.5 (53.8–868) | 131.8 (50.3–253.9) | |
| Lymph node involvement | 20 (20.8) | 14 (23) | 6 (17.1) | 0.500 |
| Distant metastasis | 76 (79.2) | 48 (78.7) | 28 (80) | 0.662 |
| Brain | 30 (31.3) | 21 (34.4) | 9 (25.7) | 0.375 |
| Liver | 31 (32.3) | 19 (31.1) | 12 (34.3) | 0.752 |
| Bone | 56 (58.3) | 34 (55.7) | 22 (62.9) | 0.496 |
| Surrenal | 50 (52.1) | 30 (49.2) | 20 (57.1) | 0.452 |
| Results were presented as n (%) or median (range). ALI – advanced lung cancer inflammation index; ECOG PS – Eastern Cooperative Oncology Group performance status; BMI – body mass index; NLR – neutrophil to lymphocyte ratio; LMR – lymphocyte to monocyte ratio; PLR – platelet to lymphocyte ratio. | ||||