Prognostic Significance of the Advanced Lung Cancer Inflammation Index in Metastatic Small Cell Lung Cancer: A Retrospective Analysis of 96 Patients

11 September 2024 : Clinical Research

Muslih Ürün

^1ABDEF, Gürkan Güner

^2AEF*, Yasin Sezgin

^1ABE, Emre Uysal

^3CDE, Abdullah Sakin

^4AE, Saadettin Kilickap

^5AE

DOI: 10.12659/MSM.945752

Med Sci Monit 2024; 30:e945752

Introduction Material and Methods Results Discussion Conclusions References

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Table 2 Prognostic factors for overall survival.

Characteristic	Univariate analysis			Multivariate analysis
Characteristic	P	OR	95% CI	P	OR	95% CI
ALI score (ref: <32.5)	0.001	0.42	0.25–0.71	0.008	0.48	0.28–0.82
ECOG PS	<0.001			0.005
0	Ref			Ref
1	0.044	1.94	1.02–3.69	0.123	1.67	0.87–3.22
2	<0.001	4.11	2.08–8.12	0.002	3.13	1.53–6.40
Weight	0.008	0.97	0.95–0.99
BMI	0.020	0.93	0.87–0.99
Albumin	0.007	0.56	0.37–0.86
Neutrophil cell/mm×10	0.011	1.13	1.03–1.24
NLR	0.008	1.09	1.02–1.15
PLR	0.035	1.002	1.001–1.003
Brain metastasis	0.003	2.08	1.28–3.38	0.002	2.17	1.32–3.56
Bone metastasis	0.005	2.05	1.24–3.38	0.002	2.27	1.36–3.80
Surrenal metastasis	0.021	1.75	1.09–2.82
OR – odds ratio; CI – confidence interval; ALI – advanced lung cancer inflammation index; ECOG PS – Eastern Cooperative Oncology Group performance status; BMI – body mass index; NLR – neutrophil to lymphocyte ratio; PLR – platelet to lymphocyte ratio.

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