18 February 2025 : Review article
Hydrogels in Oral Disease Management: A Review of Innovations in Drug Delivery and Tissue Regeneration
Li Dongwen AEF 1, Man Dapeng EF 1, Yu Jiazhi ABEF 1, Li Xiaoguang ABG 1*DOI: 10.12659/MSM.946122
Med Sci Monit 2025; 31:e946122
Table 1 Hydrogels in periodontics.
| Materials | Active ingredients | Active ingredient loading methods | Biological activity | Experiments | References |
|---|---|---|---|---|---|
| Supramolecular hydrogel SDF-1/BMP-2/NapFFY | SDF-1/BMP-2 | Coassemble | Periodontal regeneration | In vivo | []48 |
| A gelatin-based enzymatically crosslinked hydroxyphenyl propionic acid hydrogel | CAP | Chemical conjugation | Periodontal regeneration | In vitro; in vivo | []49 |
| Chitin hydrogel | ChT-1%ZnO | One-step dissolution and regeneration | Periodontal regeneration | In vitro; in vivo | []50 |
| 1,4-dihydrophenonthrolin-4-one-3-carboxylic acid (1,4-DPCA/hydrogel) | Promotes T regulatory cell recruitment and enhances alveolar bone regeneration | In vivo | []51 | ||
| PF127-BIO hydrogel | BIO | Physical mixing | Periodontal regeneration | In vitro; in vivo | []52 |
| CHI-OCS-PDLSC/GMSC hydrogel | PDLSC/GMSC | Freeze-casting | Periodontal regeneration | In vitro; in vivo | []53 |
| Chitosan/β-glycerophosphate/hydroxyapatite hydrogel | Human dental pulp stem cells | Incorporate | Periodontal regeneration | In vitro | []54 |
| Chitosan/gelatin/glycerol phosphate hydrogel | BMP-6 | Incorporate | Periodontal regeneration | In vitro; in vivo | []55 |
| Carboxymethyl-hexanoyl chitosan-β-GP-glycerol colloidal hydrogel | Naringin | Mix | Inhibition of Periodontitis | In vivo | []56 |
| Chitosan-SA/GP hydrogel | Periodontal regeneration | In vivo | []57 | ||
| CS/CSn(pDNA-BMP-2)-GP hydrogel | pDNA-BMP-2 | Embbede | Periodontal regeneration | In vitro | []58 |
| Alginate-gelatin hydrogel | PRGF | Incorporate | Periodontal regeneration | In vitro | []59 |
| GelMA/PEG hydrogel | Periodontal regeneration | In vitro | []60 | ||
| Calcium alginate hydrogel | Oral tissue reparation | In vitro; in vivo | []61 | ||
| Antibiotics/cellulose nanofiber/κ-carrageenan oligosaccharide hydrogel | surfactin | Incorporate | Antimicrobial/anti-inflamamtory | In vitro | []62 |
| HA-CHO/GC hydrogel | Ginsenoside Rg1 and amelogenin | Double-dynamic bond | Periodontal regeneration | In vivo | []63 |
| bCD-Jef-MPs/CHX-dg | CHX-dg | Incorporate | Antimicrobial | In vitro | []64 |