18 February 2025 : Review article
Hydrogels in Oral Disease Management: A Review of Innovations in Drug Delivery and Tissue Regeneration
Li Dongwen AEF 1, Man Dapeng EF 1, Yu Jiazhi ABEF 1, Li Xiaoguang ABG 1*DOI: 10.12659/MSM.946122
Med Sci Monit 2025; 31:e946122
Table 2 Hydrogels in endodontics.
| Materials | Active ingredients | Active ingredient loading methods | Biological activity | Experiments | References |
|---|---|---|---|---|---|
| Gel-BG/dECM hydrogel | dECM | Incorporate | Construct for engineering and regeneration of the pulp/dentin complex | In vitro | []65 |
| Methacrylated gelatin/thiolated pectin hydrogel | Melatonin | Carry | Pulp regeneration | In vitro | []66 |
| GelMA hydrogel | Pulp regeneration | In vitro | []67 | ||
| G-GMA/TDM hydrogel | TDM | Graft | Dentin regeneration | In vitro | []68 |
| GelMA/platelet lysate/Laponite hydrogel microsphere | PL | Incorporate | Pulp regeneration | In vivo | []69 |
| Gel-MA/NGR1 hydrogel | NGR1 | Load | Dentin regeneration | In vitro; in vivo | []70 |
| DN glycol chitosan-based hydrogel | Pulp regeneration | In vitro; in vivo | []71 | ||
| Chitosan hydrogel | CS-S | Carry | Pro-angiogenic | In vitro | []72 |
| Extracellular vesicles-loaded fibrin gel | EV | Incorporate | Pulp regeneration | In vitro | []73 |
| PCL/CS/bFGF hydrogel | bFGF | Swell | Pro-angiogenic | In vitro | []74 |
| HA/platelet lysate hydrogel | PL | Incorporate | Pulp regeneration | In vitro | []75 |
| HA/platelet lysate hydrogel | PL | Incorporate | Endodontic regeneration | In vitro | []76 |
| Tideglusib/Rg1 chitosan microsphere HA hydrogel | Tideglusib/Rg1 | Carry | Pulp regeneration | In vitro | []77 |
| CLIN-PLA-NP-loaded hydrogel | CLIN | Incorporate | Pulp regeneration | In vitro | []78 |
| Cellularized fibrin hydrogel | Pulp regeneration | In vitro | []79 | ||
| Polyethylene glycol-maleate-citrate (PEGMC) hydrogel | Calcium hydroxide | Incorporate | Endodontic treatment | In vitro | []80 |
| Supramolecular Ag-isoG hydrogel | Ag | Super-rapid in situ formation | Antimicrobial | In vitro | []81 |
| FeO-CaO-hydrogel | Nanozyme | HO modified | Root canal disinfection | In vitro; in vivo | []82 |
| Human amniotic membrane hydrogel | Dentin-pulp complex regeneration | In vitro; in vivo | []83 | ||
| Angiogenic peptide hydrogel | Self-assembling peptide | Pro-angiogenic | In vivo | []85 | |
| RAD/Dentonin hydrogel | Dentonin | Attach | Pulp regeneration | In vitro | []86 |