18 February 2025 : Review article
Hydrogels in Oral Disease Management: A Review of Innovations in Drug Delivery and Tissue Regeneration
Li Dongwen AEF 1, Man Dapeng EF 1, Yu Jiazhi ABEF 1, Li Xiaoguang ABG 1*DOI: 10.12659/MSM.946122
Med Sci Monit 2025; 31:e946122
Table 3 Hydrogel in oral mucosal disease.
| Materials | Active ingredients | Active ingredient loading methods | Biological activity | Experiments | References |
|---|---|---|---|---|---|
| HA-CNB gel | Tissue healing | In vivo | []93 | ||
| Combination film Soluplus-hydroxypropyl methylcellulose | Furosemide | Incorporate | Mucoadhesion | In vitro | []94 |
| Triamcinolone acetonide-loaded hydrogel | Acetonide | Incorporate | Mucoadhesion | In vivo | []95 |
| Alginate/chitosan-based hydrogel film | α-Mangostin | Cast and dry | Mucoadhesion | In vitro; in vivo | []96 |
| Sodium hyaluronate/45S5 bioglass composite hydrogel | Pro-angiogenic | In vitro; in vivo | []97 | ||
| Mucoadhesive Poloxamer-Based Hydrogel | HP-β-CD-Complexed Dexamethasone | Thread | Mucoadhesion | In vitro | []98 |
| PF127/HS1200/Gantrez Hydrogel | Mucoadhesion | In vitro | []99 | ||
| Composite GelMA hydrogel | dHAP | Stir | Tissue healing | In vivo | []100 |
| Light-responsive antimicrobial hydrogel | BMSCs | Carry | Tissue healing | In vitro; in vivo | []101 |
| Fe3+-tannin (Fe-TA) complex-modified P(AM-AA) hydrogel | Tissue healing | In vitro; in vivo | []102 |