18 February 2025 : Review article
Hydrogels in Oral Disease Management: A Review of Innovations in Drug Delivery and Tissue Regeneration
Li Dongwen AEF 1, Man Dapeng EF 1, Yu Jiazhi ABEF 1, Li Xiaoguang ABG 1*DOI: 10.12659/MSM.946122
Med Sci Monit 2025; 31:e946122
Table 4 Hydrogels in other oral diseases.
| Diseases | Materials | Active ingredients | Active ingredient loading methods | Biological activity | Experiments | References |
|---|---|---|---|---|---|---|
| Alveolar surgery | EMH dressing | Intraoral dressing | In vitro; in vivo | []106 | ||
| Alveolar osteitis | Carbopol 934P NF/Pluronic F-127 hydrogel | Lidocaine and metronidazole | Immerse | Simultaneous pain relief, protection from ingress of debris and pathological bacteria | In vitro | []107 |
| In situ oral cancer | Ta@PVP-DAA hydrogel | Radiosensitizer formulation | In vitro; in vivo | []114 | ||
| HPV-associated oral squamous cell carcinoma | CPBisoG hydrogel | Catechin | Heat | Drug delivery platform | In vitro; in vivo | []115 |
| Oral squamous cell carcinoma | GA-MIC-GEL hydrogel | Gambogic acid | Mix | Drug delivery | In vitro; in vivo | []116 |
| Oral squamous cell carcinoma | IR820/methylcellulose hydrogel | Doxorubicin | Stir | Drug delivery | In vitro; in vivo | []117 |
| Craniofacial bone defect | Alginate-WHMP hydrogel | Bone regeneration | In vitro; in vivo | []120 | ||
| Tissue defect | Alginate-GelMA Hydrogel Sheet | Wound healing and soft tissue regeneration | In vitro; in vivo | []121 | ||
| Bone deficiencies | a pectin/chitosan base hydrogel | HA/βTCP particles | Mix | Alveolar bone regeneration | In vitro | []122 |
| Alginate-GelMA Hydrogel | rh-BMP-2 | Encapsulated | Increase stem cell adhesion, viability, and osteogenic differentiation capacity | In vitro | []123 | |
| Oral implant | Strontium-loaded alginate scaffold | Strontium | Mix | Tissue healing | In vitro | []124 |
| Oral implant | Alginate-Catechol/PlubisSH gel | Antimicrobial peptide CTL | Mix | Limit the development of bacteria | In vitro | []125 |
| Oral implant | Dextrin-based hydrogel | DEXGEL | Mix | Bone regeneration | In vivo | []126 |