20 February 2025 : Clinical Research
Predicting Cerebral Small Vessel Disease Burden Based on Thromboelastography in Patients with Acute Ischemic Stroke: A Pilot Study
Min Xia ACE 1*, DaiZong Wu BF 1, NengWei Yu CDF 2, GuoXiang Huang BF 1DOI: 10.12659/MSM.946303
Med Sci Monit 2025; 31:e946303
Table 1 Comparison of clinical data in acute ischemic stroke patients grouped according to small vessel disease (SVD) burden scored and Fazekas score.
| Parameter | Total (n=143) | Fazekas score | SVD burden score | ||||
|---|---|---|---|---|---|---|---|
| Score ≤1 (n=88) | Score ≤2 (n=55) | p-value | Score ≤2 (n=105) | Score ≤3 (n=38) | p-value | ||
| Gender (n (%)) | |||||||
| Male | 89 (62.24%) | 56 (63.64%) | 33 (60.00%) | 0.796a | 66 (62.86%) | 23 (60.53%) | 0.953a |
| Female | 54 (37.76%) | 32 (36.36%) | 22 (40.00%) | / | 39 (37.14%) | 15 (39.47%) | / |
| Age (M(P25, P75), years) | 66.0 (57.5, 74.0) | 63.5 (54.8, 71.0) | 68.0 (64.0, 78.0) | 0.003b | 65.0 (55.0, 72.0) | 68.0 (65.0, 78.0) | 0.016b |
| NIHSS score (M(P25, P75)) | 4.0 (2.0, 7.0) | 4.0 (2.0, 5.3) | 4.0 (3.0, 8.0) | 0.261b | 4.0 (2.0, 6.0) | 4.0 (3.0, 7.8) | 0.125b |
| Hypertension (n(%)) | 91 (63.64%) | 48 (54.55%) | 43 (78.18%) | 0.007a | 60 (57.14%) | 31 (81.58%) | 0.013a |
| Diabetes (n(%)) | 50 (34.97%) | 27 (30.68%) | 23 (41.82%) | 0.239a | 34 (32.38%) | 16 (42.11%) | 0.380a |
| Hyperlipidemia (n(%)) | 70 (48.95%) | 42 (47.73%) | 28 (50.91%) | 0.843a | 49 (46.67%) | 21 (55.26%) | 0.472a |
| History of stroke (n(%)) | 16 (11.19%) | 3 (3.41%) | 13 (23.64%) | <0.001a | 7 (6.67%) | 9 (23.68%) | 0.011a |
| TOAST (n (%)) | |||||||
| LAA | 58 (40.56%) | 37 (42.05%) | 21 (38.18%) | 0.777a | 46 (43.81%) | 12 (31.58%) | 0.261a |
| SAO | 85 (59.44%) | 51 (57.95%) | 34 (61.82%) | / | 59 (56.19%) | 26 (68.42%) | / |
| FIB (M(P25, P75), g/L) | 3.19 (2.66, 3.89) | 3.01 (2.47, 3.71) | 3.47 (2.86, 3.97) | 0.012b | 3.08 (2.58, 3.83) | 3.40 (2.95, 4.10) | 0.040c |
| aPTT (M(P25, P75), s) | 27.1 (23.9, 30.8) | 27.5 (24.5, 31.0) | 26.1 (22.8, 30.1) | 0.179b | 27.5 (24.4, 30.7) | 25.7 (22.8, 30.7) | 0.279b |
| INR (M(P25, P75)) | 0.93 (0.87, 0.97) | 0.93 (0.86, 0.97) | 0.93 (0.88, 0.98) | 0.806b | 0.93 (0.86, 0.97) | 0.93 (0.88, 0.97) | 0.942b |
| PT (M(P25,P75), s) | 10.9 (10.1, 11.4) | 10.8 (10.1, 11.4) | 10.9 (10.3, 11.3) | 0.811b | 10.9 (10.1, 11.4) | 10.9 (10.2, 11.2) | 0.684b |
| TEG | |||||||
| MA (M(P25, P75), mm) | 61.8 (58.4, 64.7) | 60.4 (56.9, 63.6) | 63.1 (60.8, 66.6) | <0.001b | 60.8 (57.3, 64.1) | 64.0 (61.8, 66.7) | <0.001b |
| Angle (M (P25, P75), deg) | 66.5 (62.9, 70.2) | 65.8 (61.8, 68.9) | 69.0 (65.1, 71.3) | <0.001b | 65.7 (62.2, 69.0) | 69.8 (66.0, 71.7) | <0.001b |
| R (x±s, min) | 5.32±1.35 | 5.44±1.24 | 5.11±1.51 | 0.163c | 5.38±1.35 | 5.14±1.37 | 0.346c |
| K (M (P25, P75), min) | 1.5 (1.2, 1.8) | 1.7 (1.3, 2.0) | 1.3 (1.2, 1.7) | <0.001b | 1.6 (1.3, 1.9) | 1.3 (1.2, 1.6) | <0.001b |
| Ly30 (M(P25, P75)) | 0 (0, 0.9) | 0 (0, 0.9) | 0.1 (0, 0.8) | 0.927b | 0 (0, 0.9) | 0.0 (0, 0.7) | 0.810b |
| CI ((M(P25, P75)) | 0.80 (−0.20, 1.80) | 0.65 (−0.35, 1.40) | 1.50 (0.30, 2.40) | 0.001b | 0.70 (−0.30, 1.50) | 1.70 (0.43, 2.50) | <0.001b |
| a p: Pearson chi-squared test; b p: Kruskal-Wallis test; c p: one-way ANOVA single-factor analysis of variance. | |||||||