Hemoglobin-Albumin-Lymphocyte-Platelet Index and Risk of In-Hospital Mortality in 793 Adult Patients Hospitalized for Acute Exacerbations of Chronic Obstructive Pulmonary Disease

05 April 2025 : Clinical Research

Makbule Ozlem Akbay

^{ABCDEF 1*}, Dilek Ernam

^{AEF 1}, Lale Sertcelik

^{BCDF 1}, Fatma Ozbaki

^{BCDF 1}

DOI: 10.12659/MSM.947098

Med Sci Monit 2025; 31:e947098

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Table 4 Laboratory findings on the day of hospital admission according to in-hospital mortality.

	In-hospital mortality
	No (n=738)	Yes (n=55)	P value

WBC (10/μL)	10.0±4.0 (9.2)	11.8±4.8 (10.6)	^*
RBC (million/mm)	4.2±0.7 (4.2)	3.9±0.8 (4.0)	^*
Hemoglobin (g/dL), mean±SD	11.7±2.0 (11.8)	10.6±2.2 (10.1)	^#
Hematocrit (%)	37.1±6.0 (37.1)	34.2±7.2 (33.9)	^*
Platelet (10/μL)	271.5±101.5 (261.0)	261.1±90.3 (257.0)	0.457^*
Lymphocyte count (10/μL)	1.48±1.02 (1.30)	1.05±0.56 (0.85)	^*
Eosinophil count (10/μL)	0.10±0.15 (0.03)	0.10±0.17 (0.02)	0.297^*
Neutrophil count (10/μL)	7.6±3.4 (7.0)	9.8±4.7 (9.1)	^*
NLR	8.0±7.9 (5.5)	12.1±8.9 (11.1)	^*
PLR	264.5±201.0 (201.1)	304.7±172.6 (241.4)	^*

CRP (mg/L)	36.8±47.2 (20.3)	81.1±64.5 (62.0)	^*
Urea (mg/dL)	50.3±25.4 (45.0)	66.1±37.6 (56.0)	^*
Creatinine (mg/dL)	0.96±0.46 (0.86)	1.06±0.56 (0.92)	0.241^*
AST (U/L)	21.7±13.4 (18.0)	28.4±23.0 (22.0)	0.076^*
ALT (U/L)	23.9±19.0 (19.0)	30.1±27.2 (22.0)	0.117^*
Albumin (g/L)	35.8±4.7 (36.0)	32.6±5.5 (33.0)	^*
pH	7.40±0.06 (7.40)	7.38±0.09 (7.40)	0.845^*
pCO	52.6±12.7 (51.9)	56.3±21.1 (55.0)	0.647^*
cHCO3-(P,st), mean±SD	28.8±4.6 (29.3)	28.6±6.2 (28.7)	0.878^#
HALP score	25.8±20.5 (20.3)	15.0±9.3 (12.3)	^*
WBC – white blood cell; RBC – red blood cell; NLR – neutrophil-to-lymphocyte ratio; PLR – platelet-to-lymphocyte ratio; CRP – C-reactive protein; AST – aspartate aminotransferase; ALT – alanine aminotransferase; pCO – partial pressure of carbon dioxide; cHCO3-(P,st) – standard bicarbonate. ^* Mann-Whitney U test; ^# Independent sample test.

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