25 March 2025 : Clinical Research
Inflammatory Biomarkers in Smokers: Implications for Ligamentum Flavum Hypertrophy
Eyüp Çetin A 1*, Dilara Başgül Sagiri B 1, Eylem Burcu Kahraman Özlü D 1, Ezgi Akar BD 1, Eray Metin Güler
BD 2,3, Sarper Kocaoğlu BC 1, Hakan Beyaztaş BD 2,4, Emine Demir FG 5
DOI: 10.12659/MSM.947508
Med Sci Monit 2025; 31:e947508
Table 6 Diagnostic value of alpha-1 antitrypsin (AAT) levels in identifying smoking-induced LF hypertrophy.
| AUC area under the curve | % 95 Confidence interval | p | |||
|---|---|---|---|---|---|
| AAT | 0.867 | 0.775–0.960 | |||
| AAT 1.19 Cut-off | 0.756 | 0.629–0.882 | |||
| AAT | ≤1.19 | 14 | 26 | Sensitivity | 96.3% |
| >1.19 | 17 | 1 | Positive predictive value (PPV) | 65.0% | |
| Specificity | 54.8% | ||||
| Negative predictive value (NPV) | 94.4% | ||||
| AUC – area under the curve; CI – confidence interval; AAT – alpha-1 antitrypsin; BMI – body mass index; PPV – positive predictive value; NPV – negative predictive value; SD – standard deviation. | |||||