10 July 2025 : Clinical Research
Quantitative Multi-Parameter MRI Evaluation of Hashimoto's Thyroiditis Changes After Dietary Interventions
Ning Dai
ACDEF 1, Qi-Hao Shi CEF 1, Long-Wei Zheng BDF 1, Xiao-Shan Huang BF 1,2, Shu-Feng Fan AEG 1,2*
DOI: 10.12659/MSM.947862
Med Sci Monit 2025; 31:e947862
Table 2 Comparative pre-intervention analysis of patients with different dietary management programs in the intervention group.
| Gluten-free diet (n=5) | Low-calorie diet (n=8) | Low-carbohydrate diet (n=7) | Test statistic | P | |
|---|---|---|---|---|---|
| Age | 39.6±7.64 | 35.00±9.30 | 29.14±8.73 | 2.507* | 0.111 |
| BMI | 21.60±1.41 | 21.32±3.48 | 22.30±2.76 | 0.227* | 0.799 |
| FT3 (pmol/L) | 4.59±0.70 | 4.39±0.30 | 4.57±0.43 | 0.390* | 0.683 |
| FT4 (pmol/L) | 15.56±2.17 | 15.33±1.30 | 14.24±1.25 | 1.716** | 0.424 |
| TSH (pmol/L) | 4.14±1.41 | 2.76±1.39 | 3.24±1.32 | 1.597* | 0.231 |
| TPOAb (KU/L) | 367.67±228.09 | 562.04±399.27 | 395.08±413.42 | 0.632** | 0.729 |
| TGAb (KU/L) | 215.03±384.30 | 513.18±1110.81 | 121.12±90.26 | 1.389** | 0.499 |
| Thyroid isthmus | 4.16±1.56 | 3.52±1.04 | 4.06±1.60 | 0.630** | 0.730 |
| Thyroid left lobe (mm) | 252.94±58.49 | 244.54±35.99 | 221.71±41.38 | 1.309** | 0.520 |
| Thyroid right lobe (mm) | 241.96±27.55 | 263.90±39.10 | 223.43±34.67 | 5.324** | 0.070 |
| T1WI RSI Mean | 0.89±0.13 | 1.02±0.20 | 1.00±0.17 | 0.858* | 0.442 |
| T2WI RSI Mean | 1.78±0.39 | 1.68±0.45 | 1.69±0.35 | 0.209* | 0.814 |
| FF Mean (%) | 7.76±2.00 | 8.11±2.56 | 7.75±1.42 | 0.068* | 0.934 |
| WF Mean (%) | 94.70±1.95 | 94.56±2.31 | 94.50±1.01 | 0.343** | 0.842 |
| ADC Mean (×10 mm/s) | 1.51±0.28 | 1.45±0.20 | 1.25±0.09 | 4.757** | 0.093 |
| * The statistical method used was analysis of variance (ANOVA), with a test statistic of F; ** The statistical method used was the Kruskal-Wallis rank-sum test, with a test statistic of H. BMI – body mass index; TPOAb – thyroid peroxidase antibody; TGAb – thyroglobulin antibody; FT3 – free triiodothyronine; FT4 – free thyroxine; TSH – thyroid-stimulating hormone; T1WI RSI – T1WI relative signal intensity; T2WI RSI – T2WI relative signal intensity; FF – fat fraction; WF – water fraction; ADC – apparent diffusion coefficient. | |||||