10 July 2025 : Clinical Research
Quantitative Multi-Parameter MRI Evaluation of Hashimoto's Thyroiditis Changes After Dietary Interventions
Ning Dai
ACDEF 1, Qi-Hao Shi CEF 1, Long-Wei Zheng BDF 1, Xiao-Shan Huang BF 1,2, Shu-Feng Fan AEG 1,2*
DOI: 10.12659/MSM.947862
Med Sci Monit 2025; 31:e947862
Table 5 Comparative post-intervention analysis of patients in the intervention group with different dietary management programs.
| Gluten-free diet (n=5) | Low-calorie diet (n=8) | Low-carbohydrate diet (n=7) | Test statistic | P | |
|---|---|---|---|---|---|
| FT3 Δ | −0.57±0.79 | −0.27±0.35 | 0.04±0.28 | 1.058* | 0.369 |
| FT4 Δ | 0.59±1.92 | −0.23±1.32 | 0.47±1.05 | 0.136* | 0.874 |
| TSH Δ | −1.13±0.66 | −0.14±1.57 | 0.22±0.97 | 2.508* | 0.111 |
| TPOAb Δ | −125.59±167.30 | −203.57±189.11 | −17.22±19.24 | 4.588** | 0.101 |
| TGAb Δ | −161.06±415.47 | 2.14±6.67 | −66.06±92.60 | 2.479** | 0.290 |
| Thyroid isthmus Δ | −0.02±1.09 | −0.22±0.99 | −0.70±0.45 | 2.074** | 0.355 |
| Thyroid left lobe (mm) Δ | −7.99±7.97 | 0.31±28.71 | 1.20±1.64 | 0.740* | 0.492 |
| Thyroid right lobe (mm) Δ | 11.69±34.25 | −0.87±35.03 | 2.40±3.65 | 0.912** | 0.634 |
| T1WI RSI MeanΔ | 0.09±0.19 | −0.96±0.12 | 0.03±0.09 | 1.189* | 0.329 |
| T2WI RSI MeanΔ | −0.33±0.39 | −0.31±0.27 | −0.27±0.17 | 0.520* | 0.604 |
| FF (%) MeanΔ | −1.85±0.51 | −1.97±1.10 | −2.16±0.63 | 0.939** | 0.625 |
| WF (%) MeanΔ | 0.70±0.79 | 0.12±1.18 | 0.17±0.61 | 0.431* | 0.656 |
| ADC Mean (×10 mm/s) Δ | 0.01±0.16 | 0.04±0.22 | 0.00±0.03 | 0.555** | 0.758 |
| * The statistical method used was analysis of variance (ANOVA), with a test statistic of F; ** The statistical method used was the Kruskal-Wallis rank-sum test, with a test statistic of H. Δ The change values between the dietary regimens. BMI – body mass index; TPOAb – thyroid peroxidase antibody; TGAb – thyroglobulin antibody; FT3 – free triiodothyronine; FT4 – free thyroxine; TSH – thyroid-stimulating hormone; T1WI RSI – T1WI relative signal intensity; T2WI RSI – T2WI relative signal intensity; FF – fat fraction; WF – water fraction; ADC – apparent diffusion coefficient. | |||||