21 January 2026 : Review article
Role of Oxysterol-Binding Protein Family in Cholesterol Metabolism and Cancer Progression: A Review
Yu Wu ABCDEF 1, Xinhui Lv BC 1, Jiyuan Yang BC 1, Sicong Liu C 1, Yafang Chen A 1, Ziwen Yuan F 1, Xudong Wang AEG 2*DOI: 10.12659/MSM.949032
Med Sci Monit 2026; 32:e949032
Table 2 Oxysterol-binding protein–related proteins (ORPs), their roles in cancer and other diseases, and associated therapeutic agents.
| Protein | Cancer | Functional role | Diseases | Therapeutic agents |
|---|---|---|---|---|
| OSBP | n/a | n/a | An attractive target for the treatment of multiple RNA viruses []129 | OSW-1 is a highly specific OSBP antagonist []137 |
| ORP2 | CRC []89 | Inhibition of CRC cell migration and invasion []89 | Deficiency can lead to hypercholesterolemia and deafness []133 | n/a |
| ORP3 | CRC [], GC [], LIHC [], BC []96 | Promoting the migration and invasion of CRC [], GC [], and LIHC [] cells, but inhibiting the invasion of BC cancer cells []96 | n/a | Itraconazole binds to the ORP3-VAP-A complex and inhibits tumor cell proliferation and migration []138 |
| ORP4 | Ovarian cancer []80 | Ability to drive the proliferation of hematopoietic and ovarian cancer cells []80 | n/a | OSW-1 is a highly specific ORP4 antagonist []137 |
| ORP5 | Pancreatic cancer[], CC[], RCC[]11 | Ability to promote migration and invasion of pancreatic cancer [], CC [], and RCC [] cells11 | n/a | n/a |
| ORP8 | HCC [], GC []12 | Inhibition of HCC [],GC [] cell growth and proliferation12 | Playing a key role in the development of T2DM []134 | n/a |
| ORP9 | PDAC [], PAAD []114 | Correlating with immune infiltration of PDAC [] and PAAD [] cells114 | Knockdown delays maturation of junction-associated endocytosis structures in the testis and leads to impaired sperm release []139 | n/a |
| ORP10 | Breast cancer [], pancreatic cancer []119 | Mutations can drive breast cancer [].Promoting proliferation and metastasis of pancreatic cancer []119 | n/a | n/a |
| ORP11 | n/a | n/a | Obesity-related diseases []16 | n/a |
| OSBP – oxysterol-binding protein; CRC – colorectal cancer; GC – gastric cancer; LIHC – liver hepatocellular carcinoma; BC – breast cancer; CC – cervical cancer; RCC – renal cell carcinoma; HCC – hepatocellular carcinoma; PDAC – pancreatic ductal adenocarcinoma; PAAD – pancreatic adenocarcinoma; T2DM – type II diabetes mellitus; VAP-A – vesicle-associated membrane protein-associated protein A. | ||||