Influence of blood cell transfusion on the presence of propofol in blood components
Anna Fijałkowska, Andrzej L. Dawidowicz, Andrzej Nestorowicz, Emilia FornalMed Sci Monit 2001; 7(6): PI1334-1338 :: ID: 508408
Abstract
Background: Understanding propofol distribution in blood is important for optimizing drug usage during TIVA. We studied changes in the propofol concentration in plasma and formed blood elements separated from blood samples taken before and after transfusion of blood cells to patients during TIVA with propofol.
Material and methods: Twelve patients were studied (ASA I–II). Propofol TIVA was performed at infusion rates of 12-9-6 mg⋅kg–1⋅h–1. Fentanyl and pancuronium bromide were administered in fractional doses. After tracheal intubation the lungs were ventilated to normocapnia with oxygen-air mixture (FiO2=0.33). Blood samples for propofol analysis were taken 5 min before and 30 min after blood cell transfusion. At that point the propofol infusion rate was 6 mg⋅kg–1⋅h–1. Propofol concentrations were measured by means of HPLC.
Results: Blood cell transfusion leads to a change in the propofol level in plasma and formed blood elements. The transfusion process lowers the ratio of the plasma propofol concentration to the propofol concentration in formed blood elements.
Conclusion: Formed blood elements show a greater ability to bind propofol after transfusion of 5–15 day erythrocytes.
Keywords: Blood Transfusion, Propofol, TIVA
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
26 Mar 2024 : Clinical Research
New Computerized Planning Algorithm and Clinical Testing of Optimized Nuss Bar Design for Patients with Pec...Med Sci Monit In Press; DOI: 10.12659/MSM.943705
07 May 2024 : Clinical Research
Treatment of AVN-Induced Proximal Pole Scaphoid Nonunion Using a Fifth and Fourth Extensor Compartmental Ar...Med Sci Monit In Press; DOI: 10.12659/MSM.944553
16 Mar 2024 : Clinical Research
Diagnostic Efficiency of ACR-TIRADS Score for Differentiating Benign and Malignant Thyroid Nodules of Vario...Med Sci Monit In Press; DOI: 10.12659/MSM.943228
08 May 2024 : Clinical Research
Effect of Individualized PEEP Guided by Driving Pressure on Diaphragm Function in Patients Undergoing Lapar...Med Sci Monit In Press; DOI: 10.12659/MSM.944022
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952