The concentration of galanin in postmenopausal women before and after application of hormone replacement therapy compared to women of reproductive age
Błażej Męczekalski, Radosław Słopień, Alina Warenik-SzymankiewiczMed Sci Monit 2001; 7(5): CR928-932 :: ID: 509086
Abstract
Background: Hormone replacement therapy (HRT) during menopause exerts an essential impact on neuroendocrine regulation within the hypothalamic-pituitary system. The sex steroids, especially estrogens, are responsible for the synthesis and secretion of neuropeptides and neurotransmitters, such as galanin, neuropeptide Y, the opioid peptides, dopamine, serotonin, and others. The purpose of our research was to evaluate the concentration of galanin in postmenopausal women before and after the application of HRT, and to compare these values to the concentrations found in women of reproductive age.
Material/Methods: The experimental group consisted of 20 women (average age 53I5.2). The average time elapsed since the last menstruation in these women was 5.3 year &plusm; 1.4.
Results: The differences in the concentrations of galanin before (8.24&plusm;3.62 pg/ml) and after (5.63&plusm;2.75) the application of HRT were not statistically significant. These values were significantly lower, however (p<0.05), than the galanin concentrations in women of reproductive age (22.03&plusm;12.02 pg/ml). The concentrations of estradiol prior to the administration of HRT (0.021&plusm;0.02 ng/ml) were significantly lower (p.<0.001) than after the application of hormone replacement therapy (0.09&plusm;0.156 ng/ml). The concentrations of estradiol in the control group averaged 0.070&plusm;0.04 ng/ml, significantly higher than in the group of post-menopausal women given HRT (p.<0.05). No statistically significant difference was found between the galanin concentration in women of reproductive age and in postmenopausal women using HRT.
Conclusions: Our research results indicate that serum galanin in postmenopausal women is significantly lower than in women of reproductive age. The application of hormone replacement therapy does not restore galanin concentrations to levels typical for women of reproductive age.
Keywords: galanin, Estrogens, Menopause, menopausal symptoms
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Clinical Research
Comparing Neuromuscular Blockade Measurement Between Upper Arm (TOF Cuff®) and Eyelid (TOF Scan®) Using Miv...Med Sci Monit In Press; DOI: 10.12659/MSM.943630
11 Mar 2024 : Clinical Research
Enhancement of Frozen-Thawed Human Sperm Quality with Zinc as a Cryoprotective AdditiveMed Sci Monit In Press; DOI: 10.12659/MSM.942946
12 Mar 2024 : Database Analysis
Risk Factors of Age-Related Macular Degeneration in a Population-Based Study: Results from SHIP-TREND-1 (St...Med Sci Monit In Press; DOI: 10.12659/MSM.943140
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952