Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

02 March 1998

Peri-operative hemodilution in intracranial aneurysm surgery

Danuta Mitosek-Sabbo, Tomasz Trojanowski, Marian Czochra

Med Sci Monit 1998; 4(2): CR292-296 :: ID: 502607


Delayed cerebral ischemia is the major cause of death and disability in patients suffering from an aneurysmal subarachnoid hemorrhage (SAH). A method of reducing the risk of ischemic deficits during surgery is based on the improvement of brain microcirculation by means of hemodilution. This study presents 80 patients who underwent surgery due to SAH for ruptured intracranial aneurysms. Fifty were selected and underwent perioperative hemodilution. The other 30 comprised the control group. There were no statistically significant differences in the composition of these groups in regard to the commonly recognized prognostic factors. Moore's method was used to evaluate the circulating blood volume in patients operated on with normovolemic hemodilution. After the induction of anesthesia, 20% of the estimated volume of circulating blood was extracted and replaced by Dextran 70 000 and Ringer solution in equal parts. At the time of aneurysm clipping the hematocrit level was lowered to 0.30. In the control group it equaled 0.37. Blood was retransfused directly after aneurysm clipping or during the peri-operative bleeding. The results of treatment were evaluated at the end of the hospital stay as well as one and six months following discharge using the Glasgow Outcome Scale (GOS). Early results evaluated at the time of discharge were better in the group who were operated on using hemodilution than in the control group (GOS I-II 78% and 63.4% respectively). Surgical treatment of intracranial aneurysms using hemodilution, evaluated 6 months following discharge showed good results (GOS Grade I) in about 10% more of hemodiluted patients then in the control group. The difference was statistically significant. In addition, perioperative hemodilution reduced the need for blood transfusions.

Keywords: peri-operative hemodilution, intracranial aneurysm surgery

Add Comment 0 Comments

614 0


01 December 2023 : Editorial  

Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections

Dinah V. Parums

DOI: 10.12659/MSM.943312

Med Sci Monit 2023; 29:e943312


In Press

01 Dec 2023 : Clinical Research  

Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Clinical Research  

Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...

Med Sci Monit In Press; DOI:  

29 Nov 2023 : Clinical Research  

Comparative Analysis of Intramedullary Nail versus Plate Fixation for Fibula Fracture in Supination Externa...

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750