02 March 1998
Peri-operative hemodilution in intracranial aneurysm surgery
Danuta Mitosek-Sabbo, Tomasz Trojanowski, Marian CzochraMed Sci Monit 1998; 4(2): CR292-296 :: ID: 502607
Abstract
Delayed cerebral ischemia is the major cause of death and disability in patients suffering from an aneurysmal subarachnoid hemorrhage (SAH). A method of reducing the risk of ischemic deficits during surgery is based on the improvement of brain microcirculation by means of hemodilution. This study presents 80 patients who underwent surgery due to SAH for ruptured intracranial aneurysms. Fifty were selected and underwent perioperative hemodilution. The other 30 comprised the control group. There were no statistically significant differences in the composition of these groups in regard to the commonly recognized prognostic factors. Moore's method was used to evaluate the circulating blood volume in patients operated on with normovolemic hemodilution. After the induction of anesthesia, 20% of the estimated volume of circulating blood was extracted and replaced by Dextran 70 000 and Ringer solution in equal parts. At the time of aneurysm clipping the hematocrit level was lowered to 0.30. In the control group it equaled 0.37. Blood was retransfused directly after aneurysm clipping or during the peri-operative bleeding. The results of treatment were evaluated at the end of the hospital stay as well as one and six months following discharge using the Glasgow Outcome Scale (GOS). Early results evaluated at the time of discharge were better in the group who were operated on using hemodilution than in the control group (GOS I-II 78% and 63.4% respectively). Surgical treatment of intracranial aneurysms using hemodilution, evaluated 6 months following discharge showed good results (GOS Grade I) in about 10% more of hemodiluted patients then in the control group. The difference was statistically significant. In addition, perioperative hemodilution reduced the need for blood transfusions.
Keywords: peri-operative hemodilution, intracranial aneurysm surgery
614 0
Editorial
01 December 2023 : Editorial
Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory InfectionsDOI: 10.12659/MSM.943312
Med Sci Monit 2023; 29:e943312
In Press
01 Dec 2023 : Clinical Research
Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...Med Sci Monit In Press; DOI:
30 Nov 2023 : Review article
Decoding the Neurological Sequelae of General Anesthesia: A ReviewMed Sci Monit In Press; DOI:
30 Nov 2023 : Clinical Research
Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...Med Sci Monit In Press; DOI:
29 Nov 2023 : Clinical Research
Comparative Analysis of Intramedullary Nail versus Plate Fixation for Fibula Fracture in Supination Externa...Med Sci Monit In Press; DOI:
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292