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25 June 2015 : Clinical Research  

Relation of Serum and Vitreous Concentrations of Fetuin-A with Diabetic Retinopathy

Chunming ZhaoBC, Jiangping HouDEF, Shengxi WangDF, Rui JiangAG

DOI: 10.12659/MSM.893403

Med Sci Monit 2015; 21:1839-1842

Abstract

BACKGROUND: Fetuin-A, a liver-derived glycoprotein, is correlated with diabetes. The aim of the present investigation was to evaluate serum and vitreous concentrations of fetuin-A in patients with diabetic retinopathy (DR).

MATERIAL AND METHODS: We randomly selected 224 diabetic patients and 68 control subjects for this study.

RESULTS: There were markedly higher serum and vitreous fetuin-A concentrations in proliferative diabetic retinopathy (PDR) patients than in the other three groups. NPDR patients exhibited elevated vitreous fetuin-A concentrations compared with patients without DR. However, no significant differences in serum fetuin-A concentrations were observed between NPDR patients and patients without DR. In addition, there were significantly lower concentrations of serum and vitreous fetuin-A in control subjects compared with the other three groups.

CONCLUSIONS: The occurrence and severity of DR is correlated with serum and vitreous fetuin-A concentrations.

Keywords: Diabetic Retinopathy - metabolism, Vitreous Body - metabolism, alpha-2-HS-Glycoprotein - metabolism

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750