11 April 2024 : Animal Research
[In Press] Enhanced Bone Healing Through Systemic Capsaicin Administration: An Experimental Study on Wistar Rats
Muhammet Bahattin Bingül 1ABCDEFG, Mehmet Gül 2ABCDEFG, Serkan Dundar 3CDF, Abdulsamet Tanık 4BCDF, Gokhan Artas5CD, Mehmet Emrah Polat 1CDEFDOI: 10.12659/MSM.942485
Med Sci Monit In Press; DOI: 10.12659/MSM.942485
Available online: 2024-04-11, In Press, Corrected Proof
Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule
Abstract
BACKGROUND
The healing of bone defects is a serious challenge worldwide. One branch of dentistry deals with bone defects. Capsaicin has anti-inflammatory, anti-oxidative, and cholesterol-reducing effects. The aim of this study was to evaluate the effects of systemic capsaicin administered at different doses on bone healing.
MATERIAL AND METHODS
A total of 32 male wistar rats was used, their weight varying between 250 and 300 g. The rats were randomly divided into 4 groups of 8 rats each. The analyses served to evaluate the effect on healing of different doses of capsaicin and grafts. A significant increase was observed in the number of osteoblasts in the capsaicin-applied groups, compared with the control group.
RESULTS
The analyses served to evaluate the effect on healing of different doses of capsaicin and grafts. A significant increase was observed in the number of osteoblasts in the capsaicin-applied groups, compared with that of the control group. The inflammation scores showed a significant difference only in the control group and in the group administered with 50 mg/kg capsaicin (P=0.010). The osteoclast counts were significantly different between all groups.
CONCLUSIONS
As a result of the analyses, positive effects on bone healing were observed when capsaicin 0.25 mg/kg and 0.50 mg/kg was administered intraperitoneally. However, more studies are needed for more accurate information.
Keywords: Capsaicin; Alveolar Bone Grafting; Bone Matrix
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