20 May 2003
Analysis of blood serum lymphocytic phenotypes in chronic hepatitis C infected patients with advanced fibrosis and periodontum diseases
A. Gabriel, B. Mazur, A. Ziółkowski, K. Dąbrówka, P. Radłowski, A. Dziambor, E. Janczewska-KazekMed Sci Monit 2003; 9(2): 8-0 :: ID: 15230
Abstract
Background:Chronic hepatitis C is known to be a general systemic disorder.Few studies focus on periodontium diseases in the course of chronic viral inflammations of the liver. Aim:To analyse the relationship between the stage of periodontium disease and a number of selected lymphocytic phenotypes in blood serum of patients infected with chronic hepatitis C and advanced fibrosis. Material/Methods:The study included 28 patients (mean age of 57.3 years),whose blood serum revealed the presence of HCV-RNA,demonstrated with RT-PCR method,while biopsies helped reveal chronic hepatitis with bridge fibrosis or cirrhosis.Fibrosis was evaluated in Azan-stained preparations. Periodontal inflammation was assessed according to the following criteria:inflammation limbus, swelling, gingival pocket depth, presence of supragingival and subgingival calculus and gomphiasis. Each criterion was assigned 0 or 1 point,cumulatively from 0 to 4 points.Flow cytometry analysis included monoclonal antibodies:CD3,CD4,CD8, CD3/CD16/CD56,CD19 provided by Becton-Dickinson. Analysis of morphological parameters and fluorescence was performed with CellQuest computer software. Results:All patients with advanced liver fibrosis were found to show signs of advanced periodontium diseases (mean cumulative value of 3.25 points).The diseases most frequently encountered included:bleeding and calculus (N=28),deep gingival pockets (N=20)and gomphiasis (N=18).The grade of periodontal disease depended on the total number of T lymphocytes (p
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
12 Mar 2024 : Clinical Research
Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe PsoriasisMed Sci Monit In Press; DOI: 10.12659/MSM.943360
14 Mar 2024 : Clinical Research
Renal Dysfunction Increases Risk of Adverse Cardiovascular Events in 5-Year Follow-Up Study of Intermediate...Med Sci Monit In Press; DOI: 10.12659/MSM.943956
15 Mar 2024 : Clinical Research
Impact of One-Lung Ventilation on Oxygenation and Ventilation Time in Thoracoscopic Heart Surgery: A Compar...Med Sci Monit In Press; DOI: 10.12659/MSM.943089
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952