12 March 2024 : Review article
[In Press] Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive Strategies
Biao Li1ACEF, Kaiyao Chi1BDE, Haoran Li1BD, Jing Wang2BCF, Yanlin Zheng12ABCDOI: 10.12659/MSM.943240
Med Sci Monit In Press; DOI: 10.12659/MSM.943240
Available online: 2024-03-12, In Press, Corrected Proof
Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule
Abstract
ABSTRACT
Behçet uveitis poses significant management challenges, owing to its intricate pathogenesis and the severe prognosis it harbors, frequently culminating in irreversible visual impairment and an elevated risk of blindness. This review synthesizes contemporary insights into personalized immunosuppressive strategies for Behçet uveitis, emphasizing the necessity for a customized approach in recognition of the disease’s heterogeneity and the variable responsiveness to treatment. This discourse elaborates on the application, efficacy, and safety profiles of traditional immunosuppressants, highlighting a paradigm shift toward integrative combination therapies aimed at diminishing reliance on glucocorticoids and mitigating their associated adverse effects. This thorough evaluation seeks to enlighten clinical practices and spearhead future investigations aimed at refining the management of Behçet uveitis, championing a personalized, multidisciplinary strategy to amplify therapeutic efficacy and enhance patient quality of life.
Keywords: Uveitis; Alkylating Agents; Antimetabolites; Calcineurin Inhibitors; Behçet Syndrome
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