22 February 2002
Total IgE levels in children under three years of age.
Maciej Kaczmarski, Elzbieta MalinowskaMed Sci Monit 2002; 8(2): CR113-118 :: ID: 420930
Abstract
BACKGROUND: The course of type 1 allergic reaction is a result of compleximmune processes in which immunoglobulin E plays a crucial role. The serum level of this immunoglobulin(IgE(total)) is closely related to the age of the patient. The presented paper analyses IgE(total) inchildren below 3. MATERIAL/METHODS: The study was carried out in group of 291 patients aged 5-39 months.IgE(total) were determined using the Fluoro-FAST 3M. The analysis took into consideration the age, sexand living place of the examined children. RESULTS: The artmetic mean of IgE(total) was 38.8 +/- 4.0IU/ml, the median--12 IU/ml, whereas the 5th and 95th percentile values amounted to 1IU/ml and 185 IU/ml,respectively. According to the standards recommended by the manufacturer of reagents used for determinationof IgE(total) (Bio Whittaker), 103 children (35.4%) had elevated serum levels of IgE(total), whereas196 (67.4%) were found to have elevated IgE(total) according to population standards. The obtained percentagedistribution of elevated IgE(total) values in particular age groups is characterized by stepwise changes,observed in the age intervals for which the range of values considered as normal by the manufactureris changed. CONCLUSIONS: On the basis of analyzed IgE(total) determinations it has been established thatthe manufacturer's standards for children aged from 2 to 3 years are overestimated, whereas the populationstandards seem to be underestimated. Therefore, the determination of IgE(total) normal value range requiresfurther studies.
Keywords: Hypersensitivity, Immunoglobulin E, Sensitivity and Specificity
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
14 Mar 2024 : Clinical Research
Renal Dysfunction Increases Risk of Adverse Cardiovascular Events in 5-Year Follow-Up Study of Intermediate...Med Sci Monit In Press; DOI: 10.12659/MSM.943956
15 Mar 2024 : Clinical Research
Impact of One-Lung Ventilation on Oxygenation and Ventilation Time in Thoracoscopic Heart Surgery: A Compar...Med Sci Monit In Press; DOI: 10.12659/MSM.943089
14 Mar 2024 : Clinical Research
Differential DHA and EPA Levels in Women with Preterm and Term Births: A Tertiary Hospital Study in IndonesiaMed Sci Monit In Press; DOI: 10.12659/MSM.943895
15 Mar 2024 : Clinical Research
Evaluation of an Optimized Workflow for the Radiofrequency Catheter Ablation of Paroxysmal Atrial FibrillationMed Sci Monit In Press; DOI: 10.12659/MSM.943526
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952