14 March 2024 : Clinical Research
[In Press] Differential DHA and EPA Levels in Women with Preterm and Term Births: A Tertiary Hospital Study in Indonesia
Muhammad Alamsyah Aziz 1ABCDEFG, Dini Hidayat 1ABCDEF, Giritama Irwantoro1ABCDEF, Annisa Dewi Nugrahani 1ABCDEF, Jeffri Januar Wijaya1DEF, Siti Nadya Khairunissa Alamsyah2DEF, Nadia Larastri Almira1DEF, Tjut Sutjighassani 1DEF, Dhanny Primantara Johari Santoso 1ADEF, Sofie Rifayani Krisnadi 1AEFDOI: 10.12659/MSM.943895
Med Sci Monit In Press; DOI: 10.12659/MSM.943895
Available online: 2024-03-14, In Press, Corrected Proof
Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule
Abstract
BACKGROUND
Preterm birth is one of the main causes of neonatal death worldwide. One strategy focused on preventing preterm birth is the administration of long chain polyunsaturated fatty acids (LCPUFAs) during pregnancy. Omega-3 LCPUFAs, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are essential in metabolic and physiological processes during embryonic and fetal development. This study aimed to compare DHA and EPA levels in 44 women with preterm births and 44 women with term births at a tertiary hospital in West Java Province, Indonesia, between November 2022 and March 2023.
MATERIAL AND METHODS
A total of 88 patients in this study consisted of 44 patients with term births (≥37 gestational weeks) and 44 patients with preterm births (<37 gestational weeks) at a tertiary hospital in West Java Province, Indonesia. This observational, cross-sectional study was conducted from November 2022 to March 2023. Using the enzyme-linked immunosorbent assay test, maternal DHA and EPA levels were investigated. IBM SPSS 24.0 was used to statistically measure outcomes.
RESULTS
Average maternal DHA and EPA levels in patients with preterm births were significantly lower than those in term births. Preterm labor risk was further increased by DHA levels of ≤5.70 µg/mL (OR=441.00, P=0.000) and EPA levels ≤3971.54 µg/mL (OR=441.00, P=0.000).
CONCLUSIONS
Since the average maternal DHA and EPA levels were significantly lower in patients with preterm births, adequate intake of omega-3 LCPUFA in early pregnancy and consistency with existing nutritional guidelines was associated with a lower risk of preterm delivery for pregnant women.
Keywords: 6,7-dihydroxy-1,2,3,4,8,12b-hexahydroanthr(10,4a,4-cd)azepine; Premature Birth; Eicosapentaenoate-Lipoate
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