01 July 2006
Primary cutaneous malignant fibrous histiocytoma: A case report.
Ashitha C. Bose, Vikram Kate, Nilakantan Ananthakrishnan, Sowmya SrinivasanMed Sci Monit 2006; 12(7): CS61-63 :: ID: 452210
Abstract
Background: Malignant fibrous histiocytoma (MFH) is one of the commonestsoft tissue sarcomas to occur in the extremities, but presentation as a primary cutaneous lesion is rare.MFH can present as a cutaneous lesion in the form of a primary tumor or as metastasis from MFH at othersites, such as primary MFH of the breast; however, both presentations are very rare. Case Report: Wereport here a 55-year-old male patient with cutaneous MFH on the right thigh region. The patient presentedwith two swellings on the outer aspect of the thigh of three months' duration, which ulcerated followingthe first month. The swellings were non-tender, soft, compressible, and not fixed to underlying structures.Histopathologic examination of the excised tumor revealed highly pleomorphic spindle-shaped cells arrangedin sheets and irregular fascicles with a focal storiform pattern. Many thin-walled blood vessels andfocal inflammatory cell infiltration with occasional focus of myxoid change was seen. Storiform-pleomorphictype of MFH grade II was diagnosed. Wide local excision was done. The patient made an uneventful recovery.Conclusions: Although MFH is one of the commonest soft tissue sarcomas, cutaneous presentation is veryrare. A high index of suspicion is necessary to keep this possibility in mind, as it can present in differentforms, including the pedunculated types, which can be compressible. MFH variants such as atypical fibroushistiocytoma or atypical fibroxanthoma can occur sometimes as cutaneous MFH. Wide local excision is commonlypossible in most of the cases for therapy.
Keywords: Histiocytoma, Malignant Fibrous - surgery, Skin Neoplasms - surgery
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
12 Mar 2024 : Clinical Research
Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe PsoriasisMed Sci Monit In Press; DOI: 10.12659/MSM.943360
14 Mar 2024 : Clinical Research
Renal Dysfunction Increases Risk of Adverse Cardiovascular Events in 5-Year Follow-Up Study of Intermediate...Med Sci Monit In Press; DOI: 10.12659/MSM.943956
15 Mar 2024 : Clinical Research
Impact of One-Lung Ventilation on Oxygenation and Ventilation Time in Thoracoscopic Heart Surgery: A Compar...Med Sci Monit In Press; DOI: 10.12659/MSM.943089
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952