01 October 2007
Recent advances in tumor hypoxia: Tumor progression, molecular mechanisms, and therapeutic implications
Yuqing Zhang, Min Li, Qizhi Yao, Changyi ChenMed Sci Monit 2007; 13(10): RA175-180 :: ID: 502434
Abstract
Tumor oxygenation status is tightly regulated and correlates with its aggressive behavior. Hypoxia plays critical roles in tumor progression including tumor angiogenesis, mutation rate, metastasis and resistance to radiation and chemotherapy. Many molecular pathways have been recognized to mediate these hypoxia-induced responses in tumors. For example, extensive studies demonstrate that hypoxia-inducible factor-1 (HIF-1) is a key molecule in regulating tumor responses to hypoxia. Many other genes including growth factors, glycolytic enzymes, cytokines, and transcription factors are inducible by hypoxia via either HIF-1-dependent or HIF-1-independent pathways. This review summarizes current advances in tumor hypoxia regarding new technologies of tumor hypoxia measurement, clinical and animal studies, cell culture models, the hypoxia-induced key molecules and therapeutic implications. This valuable information is particularly timely and helpful for clinicians and researchers who want to recognize the newest endeavors within the field and identify possible lines of investigation in tumor hypoxia.
Keywords: Disease Progression, Anoxia - therapy, Neoplasms - therapy, Oxygen - metabolism, Tumor Cells, Cultured
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
07 May 2024 : Clinical Research
Treatment of AVN-Induced Proximal Pole Scaphoid Nonunion Using a Fifth and Fourth Extensor Compartmental Ar...Med Sci Monit In Press; DOI: 10.12659/MSM.944553
16 Mar 2024 : Clinical Research
Diagnostic Efficiency of ACR-TIRADS Score for Differentiating Benign and Malignant Thyroid Nodules of Vario...Med Sci Monit In Press; DOI: 10.12659/MSM.943228
08 May 2024 : Clinical Research
Effect of Individualized PEEP Guided by Driving Pressure on Diaphragm Function in Patients Undergoing Lapar...Med Sci Monit In Press; DOI: 10.12659/MSM.944022
21 Mar 2024 : Clinical Research
Impact of Serum Vitamin D, B6, and B12 and Cognitive Functions on Quality of Life in Peri- and Postmenopaus...Med Sci Monit In Press; DOI: 10.12659/MSM.943249
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952