21 March 2024 : Clinical Research
[In Press] Impact of Serum Vitamin D, B6, and B12 and Cognitive Functions on Quality of Life in Peri- and Postmenopausal Polish Women
Dorota Raczkiewicz 1BCDE, Mariusz Gujski 2CEF, Beata Sarecka-Hujar 3DEF, Krzysztof Suski1EF, Agnieszka Pedrycz-Wieczorska 4CEF, Artur Wdowiak 5BCE, Iwona Bojar 6ABEGDOI: 10.12659/MSM.943249
Med Sci Monit In Press; DOI: 10.12659/MSM.943249
Available online: 2024-03-21, In Press, Corrected Proof
Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule
Abstract
BACKGROUND
Menopause initiates or accelerates health problems in a woman’s life, and affects cognitive processes and quality of life. We aimed to assess the quality of life, cognitive functions, and serum vitamin D, B6, and B12 concentrations in perimenopausal and postmenopausal Polish women. Also, we correlated the assessment of the quality of life with these vitamin concentrations and cognitive functions.
MATERIAL AND METHODS
The study was conducted in 287 perimenopausal and postmenopausal women. Serum levels of vitamin D, B6, and B12, cognitive functions using CNS Vital Signs software, and quality of life using WHO Quality of Life Brief were tested.
RESULTS
Almost all of the perimenopausal and postmenopausal women had normal concentrations of serum vitamin B12 (96%), 80% of them had normal B6 concentration, while only 9% had optimal serum vitamin D concentration. Postmenopausal women had lower Neurocognitive Index, psychomotor speed, motor speed, reaction time, and lower assessment of overall quality of life, physical health, and social relationships compared to perimenopausal women. In comparison to postmenopausal women, perimenopausal women had a lower serum vitamin B6 concentration, and the lower the concentration of this vitamin in serum they had, the lower they assessed their environment. Perimenopausal women assessed their social relationships the better, the better the visual memory, and the lower the processing speed they had. Postmenopausal women assessed the environment the better, the higher their Neurocognition Index was, and the better the reaction time they had.
CONCLUSIONS
Assessment of quality of life was associated with some cognitive functions in both perimenopausal and postmenopausal women.
Keywords: Cognitive Dysfunction; Menopause; Perimenopause; Postmenopause; Quality of Life; Vitamins
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