Adverse reactions to interferon alpha (INF alpha) treatment in children with chronic viral hepatitis
Anna Szaflarska-Szczepanik, Ewa Łoś, Andrzej Chrobot, Kinga Michalska, Mieczysława Czerwionka-SzaflarskaMed Sci Monit 1999; 5(5): CR878-884 :: ID: 503346
Abstract
The aim of the study was to evaluate adverse reactions to the treatment with interferon alpha in children with chronic hepatitis B and/or C. 162 children, both boys and girls aged 1-16 years, who completed the treatment with interferon were included in our analysis. Adverse reactions were compared in relation to the type of hepatotropic virus, patient's age, gender and concomitant diseases. We also analysed whether there was any correlation with the kind of medicinal product used INFa (or Roferon).The study revealed that different adverse reactions following interferon-therapy occurred in 84% children. The most common included: higher body temperature, lack of appetite, osteoarticular and muscular pain and anaemia. There were no significant differences in the occurrence of these reactions in relation to virus type and patients' gender. On the other hand, slight differences were observed in children from various age groups and between those treated with various interferon preparations. Side effects (autoimmune complications, convulsions) required the discontinuation of therapy only in 4 children (2.5%).Summing up, children with chronic hepatitis B and/or C treated with interferon a frequently display adverse reactions, but in the majority of cases these side effects are of mild intensity and allow for the continuation of treatment.
Keywords: children, chronic viral hepatitis, interferon alpha
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
11 Mar 2024 : Clinical Research
Enhancement of Frozen-Thawed Human Sperm Quality with Zinc as a Cryoprotective AdditiveMed Sci Monit In Press; DOI: 10.12659/MSM.942946
12 Mar 2024 : Database Analysis
Risk Factors of Age-Related Macular Degeneration in a Population-Based Study: Results from SHIP-TREND-1 (St...Med Sci Monit In Press; DOI: 10.12659/MSM.943140
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952