06 May 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury After Massive Burns
Wojciech Klimm 1ABCDEFG*, Katarzyna Szamotulska 2ABCDEF, Marek Karwański 3CDE, Zbigniew Bartoszewicz4ABCDE, Wojciech Witkowski5ABCDE, Tomasz Rozmyslowicz6DEF, Stanisław Niemczyk 1ABCDEFGDOI: 10.12659/MSM.943500
Med Sci Monit 2024; 30:e943500
Abstract
BACKGROUND: Acute kidney injury (AKI) is a common and serious complication after massive burn injury. One of the postulated etiologies is destruction of the extracellular matrix of nephrons, caused by a local imbalance between matrix metalloproteinases (MMPs) and specific inhibitors. The aim of this study was to analyze the dynamics of tissue inhibitors of metalloproteinases (TIMPs) during the first 5 days after massive thermal injury and the relationship with the risk of AKI.
MATERIAL AND METHODS: Thirty-three adults (22 men, 11 women) with severe burns were enrolled in the study. The values of TIMPs 1 to 4 were measured in blood serum and urine using the multiplex Luminex system. The associations between TIMPs and the risk of AKI were analyzed by using the generalized linear mixed models for repeated measurements.
RESULTS: Significant changes in serum and urine activities of TIMPs were confirmed, especially during the first 2 days after burn injury. Almost half of patients presented renal problems during the study. Significant differences between values of TIMPs in AKI and non-AKI status were also observed. However, a significant relationship between concentration of TIMPs and risk of AKI was confirmed only for urine TIMP-1 and serum TIMP-3.
CONCLUSIONS: The evaluation of TIMPs in the early stage after burn injury has potential benefits. The important roles of urine TIMP-1 and serum TIMP-3, as novel markers of the risk of AKI development, were confirmed. Other parameters require further analysis.
Keywords: Burn Units, Acute Kidney Injury, Matrix Metalloproteinase Inhibitors, TIMP2 Protein, Human, TIMP1 Protein, Human
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