01 August 2011
Review of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing’s sarcoma
Xing Dai, Wei Ma, Xijing He, Rajiv Kumar JhaDOI: 10.12659/MSM.881893
Med Sci Monit 2011; 17(8): RA177-190
Abstract
The most prevalent forms of bone cancer are osteosarcoma, chondrosarcoma, and Ewing’s sarcoma. Although chemotherapy and radiotherapy have replaced traditional surgical treatments, survival rates have undergone only marginal improvements. Current knowledge of the molecular pathways involved in each type of cancer has led to better approaches in cancer treatment. A number of cell signaling molecules are involved in tumorigenesis, and specific targets have been identified based on these signal transducers. This review highlights some of the important cellular pathways and potential therapeutic targets, tumor site-specific irradiation techniques, and novel drug delivery systems used to administer these drugs.
Keywords: Sarcoma, Ewing - therapy, Osteosarcoma - therapy, Chondrosarcoma - therapy, Bone Neoplasms - therapy, Tumor Markers, Biological - metabolism
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