Scimago Lab
powered by Scopus
Formerly the IP & Science
business of Thomson Reuters


eISSN: 1643-3750

Get your full text copy in PDF

Ultrastructure of the placental barrier in samples from pregnancies complicated by fetal hypertrophy: a preliminary report

Adam Ziółkowski, Krystyna Olech, Henryk Grzybek, Andrzej Gabriel, Natalia Matysiak, Krzysztof Jasik, Maria Sozańka, Jan Łaskawiec, Sławomir Pawłowski, Zbigniew Szczurek

Med Sci Monit 1997; 3(2): BR149-153

ID: 500627

The present study includes assessment of morphological and ultrastructural differences in the afterbirth from pregnancies complicated by fetal hypertrophy (9 cases- a study group) as opposed to those from full-term pregnancies (10 cases - a control group). Abnormalities were evaluated macroscopically and on light and transmission electron microscopy. Macroscopic placental examination showed no evidence of focal abnormalities. Light microscopy (histopathological evaluation) of samples from hypotrophic pregnancies showed a decreased intervillous space with a simultaneous increase in the size of the villi, congestion of the villi and intervillous space. Additionally, moderate and severe fibrosis was noted. Transmission electron microscopy of the majority of samples showed oedema of the villous endothelial cells as well as exfoliation of the cells from the basal membrane and filling in of the new space by collagen fibres. Rugosity and thickening of the basal membrane was present. In severe endothelial exfoliation an increased number of lysosomes in the trophoblast cells directed towards the intervillous space. In the group of placentas from full-term pregnancies, moderate oedema was found in the endothelial cells, and in some cases mild trophoblast vacuolisation was also present.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree