Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

15 May 2002

The rate of loss of eyelid reflex following thiopental administration in hypo-and hypergonadism in rabbits.

Beata Badowicz, Andrzej Starczewski, Bogdan Szymański, Leon Drobnik, Cezary Pakulski

Med Sci Monit 2002; 8(5): BR179-183 :: ID: 420848

Abstract

BACKGROUND: The aim of this research was to explain whether different hormonalconditions caused by disturbed concentrations of estrogens and progesterone might lead to alterationof CNS reaction following administration of the hypnotic agent thiopental. The investigated factor wasthe rate of loss of the eyelid reflex after intravenous thiopental administration, since this correspondswith loss of consciousness. MATERIAL/METHODS: The investigation was performed in 24 sexually mature femaleChinchilla rabbits divided into 4 groups of 6 rabbits each. The animals were oophorectomized (hypoprogesterone/hypoestrogen),hyperestrogen (sham surgery plus estradiol injections), hyperprogesterone (sham surgery plus 17 alpha-hydroxyprogesteroneinjections), or normal (sham surgery). Twelve weeks later, thiopental (40 mg/ml) was infused throughthe intravenous cannula at a constant rate (90 ml/hour) until loss of the eyelid reflex, at which timeblood was sampled for determination of thiopental, b-estradiol, progesterone and 17 alpha-hydroxyprogesteroneconcentrations. The ANOVA and Tukey tests were applied in statistical analysis (p=0.05). RESULTS: Hyperprogesteronerabbits lost consciousness faster (138 +/- 34.6 sec), at a lower plasma thiopental concentration (46.3+/- 6.6 microg/ml), and required less thiopental (24.63 +/- 6.44 mg/kg) than controls; hypoprogesteronerabbits lost consciousness slower (207.5 +/- 30.9 sec), at a higher plasma thiopental concentration (129.2+/- 24.9 microg/ml), and required more thiopental (38.51 +/- 2.33 mg/kg) than controls. The time of sleepinduction in the control group was 190 +/- 25.7 sec.; the serum thiopental concentration was 77.8 +/-13.9 microg/ml, and the total thiopental consumption was 35.8 +/- 3.51 mg/kg. Estrogen status has noeffect. CONCLUSIONS: Various hormonal states are accompanied by different CNS reactions to thiopental.Among the studied groups of sex steroids, only progestins significantly modify the CNS response to barbiturateinfusion.

Keywords: 17-alpha-Hydroxyprogesterone, Anesthetics, Intravenous, Central Nervous System, Eyelids, Gonadal Disorders, Hypogonadism, Progestins, Reflex, Thiopental, Time Factors

Add Comment 0 Comments

Editorial

01 April 2024 : Editorial  

Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug Resistance

Dinah V. Parums

DOI: 10.12659/MSM.944600

Med Sci Monit 2024; 30:e944600

0:00

In Press

06 Mar 2024 : Clinical Research  

Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...

Med Sci Monit In Press; DOI: 10.12659/MSM.941102  

06 Mar 2024 : Clinical Research  

Prevalence and Variation of Medical Comorbidities in Oral Surgery Patients: A Retrospective Study at Jazan ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943884  

08 Mar 2024 : Clinical Research  

Evaluation of Foot Structure in Preschool Children Based on Body Mass

Med Sci Monit In Press; DOI: 10.12659/MSM.943765  

15 Apr 2024 : Laboratory Research  

The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in Osteoarthritis

Med Sci Monit In Press; DOI: 10.12659/MSM.943738  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750