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01 November 2005

Serum retinol and total carotene concentrations in obese pre-school children.

Roseli Saccardo Sarni, Rosell Oselka Saccardo Sarni, Rejane Ramalho, Denise de Oliveira Schoeps, Cristiane Kochi, Priscila Catherino, Maria Carolina Pires Dias, Cristiane Ximenes Pessotti, Lilian de Queirós Mattoso, Fernando Basile Colugnati

Med Sci Monit 2005; 11(11): CR510-514 :: ID: 430363


Background: Obesity among pre-school children and its repercussions onadult life are growing problems, but there has been little research focusing on its relationship withthe deficiency of serum retinol and carotenoids in our region. Material/Methods: In a case-control study,a group of 46 preschool children, were matched by sex and age (23 obese and 23 non-obese subjects; averageage 5.74 and 5.76 years, respectively). Serum retinol and carotenoid levels were evaluated accordingto Underwood and Sauberlich. Other aspects evaluated included nutritional status using the weight/heightz-score (Obesity ZWH >/=2), serum levels of triglicerides (TG), total cholesterol (TC) and the VLDL-c,HDL-c, and LDL-c fractions, classified according to Kwiterovich. Results: Serum retinol insufficiencywas 18.2% vs. 6.7% (p=0.38) for cases and controls, respectively. Low carotenoid levels were found inthe obese in relation to the non-obese (82% vs. 26,6%, p=0,0054 and OR=12,4). No statistically significantdifference between the case and control groups was found for TC and cholesterol fractions, TG and retinol.The findings for the tested parameters were as follows: high TC (cases 30.4%, controls 21.7%; p=0.50),LDL-c (cases and controls 34.8%; p=0.50), low HDL-c (cases 17.4%, controls 26%; p=0.47), high TG (cases31.8%, controls 17.4%, p=0.65) and high VLDL-c (cases 21.7% and controls 8.7%; p=0.20). Conclusions:The association of obesity, hyperlipidemia and low serum level of carotenoids, which are essential toantioxidant protection, may be one of many factors predisposing obese children to a high risk of atherosclerosislater in life.

Keywords: Child, Case-Control Studies, Carotenoids - blood, Child, Preschool, Disease Susceptibility, Obesity - etiology, Vitamin A - blood

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750