01 September 2006
Knee osteonecrosis due to lead poisoning: Case report and review of the literature
Konstantinos Kazakos, Christos Chatzipapas, Konstantinos C. Xarchas, Michael Mantatzis, Konstantinos Tilkeridis, Vasilios Galanis, Dionisios A. VerettasMed Sci Monit 2006; 12(9): CS85-89 :: ID: 455266
Abstract
Background:Though rare, a relationship between toxic heavy-metal accumulation and bone necrosis exists.
Case Report: A 28-year-old man suffered from chronic bilateral knee pain accompanied by muscle fibrillations and night cramps. On examination he presented tenderness and mild quadriceps muscle atrophy, but unaffected range of movement, sensation, and tendon reflexes and no effusion. He also complained of blurred vision, lethargy, and tremor.The symptoms of this mild encephalopathy combined with the patient’s history led the differential diagnosis to heavy-metal poisoning. The patient’s knees were evaluated by x-ray, skeletal scintiscan Tc99m MDP, and MRI scan. All imaging findings were pathognomonic for bone infarction. His treatment included calcium disodium edetate i.v with dimercaprol followed by succimer p.o, non-weight bearing, and physiotherapy. The symptoms of his mild encephalopathy subsided as did the knee discomfort and tenderness.
Conclusions:On the basis of these data it appeared that these infarcts were attributable to lead poisoning. This situation has not been described in the knee region, but further clarification of a possible causal relationship between toxic trace element concentration and idiopathic bone necrosis appears necessary.
Keywords: Knee Joint - pathology, Lead Poisoning - complications, Osteonecrosis - etiology
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
16 Mar 2024 : Clinical Research
Diagnostic Efficiency of ACR-TIRADS Score for Differentiating Benign and Malignant Thyroid Nodules of Vario...Med Sci Monit In Press; DOI: 10.12659/MSM.943228
08 May 2024 : Clinical Research
Effect of Individualized PEEP Guided by Driving Pressure on Diaphragm Function in Patients Undergoing Lapar...Med Sci Monit In Press; DOI: 10.12659/MSM.944022
21 Mar 2024 : Clinical Research
Impact of Serum Vitamin D, B6, and B12 and Cognitive Functions on Quality of Life in Peri- and Postmenopaus...Med Sci Monit In Press; DOI: 10.12659/MSM.943249
17 Mar 2024 : Clinical Research
Protective Role of TRPC3 Gene Polymorphism (rs10518289) in Obstructive Sleep Apnea Hypopnea Syndrome Among ...Med Sci Monit In Press; DOI: 10.12659/MSM.942667
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952