Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

30 March 2007

Serum magnesium and calcium ions in patients with severe pre-eclampsia/eclampsia undergoing magnesium sulfate therapy

Shahnaz Aali, Payam Khazaeli, Fatemeh Ghasemi, Anahita Mehdizadeh

Med Sci Monit 2007; 13(4): CR191-194 :: ID: 481104

Abstract

Background:Magnesium sulfate is used for seizure therapy and prophylaxis in women with eclampsia and pre-eclampsia worldwide. Magnesium may act by opposing calcium-dependent arterial constriction and may also antagonize the increase in intracellular calcium concentration. The objectives were to study the alterations in serum ionized magnesium and calcium and their relationship in patients with severe pre-eclampsia/eclampsia receiving magnesium sulfate therapy.
Material/Methods:Fifty patients in singleton pregnancy with severe pre-eclampsia or eclampsia who were candidates for intravenous magnesium sulfate infusion were studied. Serum ionized magnesium and calcium concentration were determined in blood samples taken before magnesium sulfate infusion, 30 and 240 minutes after the initiation of the infusion, and 4 hours after discontinuation of the therapy. Repeated-measure ANOVA, paired t-test, and Pearson’s correlation coefficient were used to analyze the data.
Results:Mean baseline levels of ionized magnesium and ionized calcium were 1.3±0.5 mEq/l and 3.8±0.5 mg/dl, respectively. The mean concentration of ionized magnesium changed significantly at the stated intervals, while mean ionized calcium values did not. Significant correlation was found between ionized calcium and magnesium four hours after the initiation of magnesium sulfate infusion and after discontinuation of the therapy.
Conclusions:Magnesium ion does not appear to exert its therapeutic effect in pre-eclampsia/eclampsia by substantially modulating serum ionized calcium. However, the effect of exogenous Mg on intracellular calcium cannot be ruled out.

Keywords: Analysis of Variance, Calcium - blood, Eclampsia - drug therapy, Magnesium - blood, Magnesium Sulfate - therapeutic use, Pre-Eclampsia - drug therapy, Pregnancy, Time Factors

0 Comments

Editorial

04 June 2022 : Editorial  

Editorial: Acute Hepatitis of Unknown Origin in Children. Is Autoimmunity at Play?

Nahum Mendez-Sanchez, Shreya C. Pal
Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico

DOI: 10.12659/MSM.937371

Med Sci Monit 2022; 28:e937371

SARS-CoV-2/COVID-19

27 June 2022 : Clinical Research  

Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...

Med Sci Monit In Press; DOI: 10.12659/MSM.937430  

27 May 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit 2022; 28:e936547

In Press

27 Jun 2022 : Clinical Research  

Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...

Med Sci Monit In Press; DOI: 10.12659/MSM.937430  

27 Jun 2022 : Clinical Research  

Automatic Identification of Depression Using Facial Images with Deep Convolutional Neural Network

Med Sci Monit In Press; DOI: 10.12659/MSM.936409  

23 Jun 2022 : Clinical Research  

A Real-World Study to Compare the Safety and Efficacy of Paritaprevir/Ombitasvir/Ritonavir and Dasabuvir, w...

Med Sci Monit In Press; DOI: 10.12659/MSM.936706  

22 Jun 2022 : Clinical Research  

A Single-Center Study Comparing the Effects of Thoracic Spine Manipulation vs Mobility Exercises in 26 Offi...

Med Sci Monit In Press; DOI: 10.12659/MSM.937316  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750