Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 September 1998

Fluid-attenuated inversion-recovery sequence in the evaluation of cerebrovascular lesions

Jolanta Sikorska, Jerzy Walecki, Elżbieta Jurkiewicz, Danuta Mróz, Wiesław Drozdowski, Ewa Str—óżyńska

Med Sci Monit 1998; 4(5): MT889-896 :: ID: 502078

Abstract

FLAIR (Fluid-Attenuated Inversion-Recovery) is a new sequence applied in MR neuroimaging that uses signal suppression of tissues with lengthened relaxation time, e. g. of cerebrospinal fluid. FLAIR images are characterised with high contrast between normal cerebral tissues and pathological lesions. The aim of the study was to compare the diagnostic value of FLAIR as well as spin-echo sequences and CT images for the assessment of cerebrovascular lesions in patients with symptoms of cerebral circulatory failure. 102 patients were divided into two groups depending on subclinical and clinical form of cerebral ischaemic stroke. The following examinations were performed in all the subjects: CT, MR in standard spin-echo sequences (SE, FSE) as well as in fast spin-echo FLAIR sequence (FSE FLAIR) in 0.5 and 1.5 T. The analysis included the number, size, location and morphology of lesions, relating these to patients' clinical status. Diagnostic value of CT, SE and FLAIR were evaluated, assuming FLAIR as a reference method. Among patients with transient cerebral ischaemia, no lesions were detected in CT and MR examinations in 35% patients. CT sensitivity in lesion detection was 19.6% (p=0.0126), and in SE sequence - 68.6% in relation to FLAIR (p < 0.0001) at high specificity of both methods 100&percnt;. The lesions were detected in all the patients with cerebral infarction. MR usually confirmed the presence of stroke areas visible during CT, thus the sensitivity of both techniques in the detection of lesions was higher than in the previous group. CT sensitivity was 62.5% (p=0.0007), SE sequence - 79.1%in relation to FLAIR (p < 0.0001), specificity of both methods 100%.
LAIR allowed for the visualisation of more cerebrovascular lesions located in brain hemispheres (cortex and white matter), stem and cerebellum, while the number of lesions detected within basal ganglia and thalamus was similar. FLAIR images were highly sensitive in the detection of small gliosis foci, apoplectic cysts and secondary haemorrhagic lesions at various stages of evolution. They allowed for a more accurate assessment of the extent of foci and ischaemic zones, including early lesions, as well as for the differentiation of lacunar stroke from broadened Virchow-Robin spaces.
FLAIR method is particularly useful in the diagnostics of lesions located in the proximity of cerebrospinal fluid, especially for the detection of cortical foci. It enables the detection and differentiation of vascular foci at various stages of evolution, including early lesions that are not visualised in CT and standard MR imaging.

Keywords: Magnetic Resonance Imaging, spin-echo sequences, cerebral infarction, saturation, Diffusion-weighted imaging, Cerebrovascular Disorders

Add Comment 0 Comments

Editorial

01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

Database Analysis  

Long-Term Prognosis of Patients Undergoing Percutaneous Coronary Intervention: The Impact of Serum Creatini...

Med Sci Monit In Press; DOI: 10.12659/MSM.943063  

Database Analysis  

Maternal Exposure to Environmental Air Pollution and Premature Rupture of Membranes: Evidence from Southern...

Med Sci Monit In Press; DOI: 10.12659/MSM.943601  

Animal Research  

Enhanced Bone Healing Through Systemic Capsaicin Administration: An Experimental Study on Wistar Rats

Med Sci Monit In Press; DOI: 10.12659/MSM.942485  

Clinical Research  

Differential Inflammatory Responses in Adult and Pediatric COVID-19 Patients: Implications for Long-Term Co...

Med Sci Monit In Press; DOI: 10.12659/MSM.944052  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750