Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 2008

Temporal clustering analysis: what does it tell us about the resting state of the brain?

Victoria L MorganABCDEFG, John C GoreABDEFG, Jerzy P SzaflarskiABDEFG

Med Sci Monit 2008; 14(7): CR345-352 :: ID: 863662

Abstract

Background
Several networks of synchronous blood oxygen level dependent (BOLD) oscillations have been identified in the brain during the resting state. The aim of this study was to further characterize the dynamic nature of the brain at rest by investigating the presence and distribution of coherent, transient BOLD activity in resting fMRI data using a novel method of fMRI data analysis--2dTCA.
Material and Method
High-field fMRI data were acquired in 27 subjects. The temporal clustering analysis, 2dTCA, was implemented to determine the timing of significant, spatially coherent, transient BOLD signal changes. Group maps of positive and negative coherent BOLD changes from each timing profile were created.
Results
Spontaneous increases in BOLD activity at both 3T and 4T and decreases at 4T were found in regions of the alpha rhythm circuit including the thalamus, precuneus and the occipital cortex. Additional positive and negative oscillations at 4T and a small region of positive activity at 3T were identified in the area of the brain stem reticular formation, the control center for maintaining arousal and motivation.
Conclusions
These results provide additional evidence for the presence of dynamic functional networks in the resting brain that are active while the subjects appear to be at rest and that are spatially distributed in areas responsible for maintaining consciousness and vigilance including brain stem. These findings should be considered in interpreting fMRI results which use resting baseline for comparisons.

Keywords: Oxygen - blood, Cluster Analysis, Brain Mapping, Time Factors, Rest - physiology, Brain - physiology, Algorithms

Add Comment 0 Comments

Editorial

01 November 2024 : Editorial  

Editorial: Artificial Intelligence (AI), Digital Image Analysis, and the Future of Cancer Diagnosis and Prognosis

Dinah V. Parums

DOI: 10.12659/MSM.947038

Med Sci Monit 2024; 30:e947038

0:00

In Press

Clinical Research  

Plaque Removal and Gingival Bleeding Using Biodegradable Toothbrushes: Salvadora persica, Bamboo, and Nylo...

Med Sci Monit In Press; DOI: 10.12659/MSM.944469  

0:00

Clinical Research  

Comparative Analysis of Extended Curettage with Plate Fixation and Extended Curettage with Intramedullary N...

Med Sci Monit In Press; DOI: 10.12659/MSM.945157  

Clinical Research  

Clinical Outcomes of Talus Bone Marrow Edema: Comparing Plaster Cast, Crutches, and Walking Boot Treatments

Med Sci Monit In Press; DOI: 10.12659/MSM.946072  

Review article  

Comprehensive Insights into Arecoline Hydrobromide: Pharmacology, Toxicity, and Pharmacokinetics

Med Sci Monit In Press; DOI: 10.12659/MSM.945582  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,263,065

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,908,785

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   695,294

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

07 Jan 2022 : Meta-Analysis   260,437

Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...

DOI :10.12659/MSM.935074

Med Sci Monit 2022; 28:e935074

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750