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08 November 2013

Effect of methoxy polyethylene glycol-epoetin beta on oxidative stress in predialysis patients with chronic kidney disease

Piotr BartnickiABCDEFG, Paweł FijałkowskiABCDEFG, Małgorzata MajczykABCDEFG, Jan BłaszczykABCDEFG, Maciej BanachABCDEFG, Jacek RyszABCDEFG

DOI: 10.12659/MSM.884024

Med Sci Monit 2013; 19:954-959

Abstract

Background
There is data in the literature indicating increased oxidative stress in chronic kidney disease (CKD). Erythropoiesisstimulating agents (ESAs), which are commonly used to treat anemia in patients with CKD, seem to have an antioxidant action, which could be a part of nephroprotection. The aim of the current study was to investigate the effect of a long half-life ESA, methoxy polyethylene glycol-epoetin beta (Mircera), on some markers of oxidative stress in predialysis patients with CKD.
Material and Methods
Peripheral blood was collected from 28 predialysis CKD patients 2 times, before Mircera treatment and after achieving target hemoglobin (Hb), and 15 healthy subjects (control group). Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activity in erythrocytes were measured according to commonly used methods as a function of the antioxidant defense system. To assess reactive oxygen species (ROS) production, malondialdehyde (MDA) concentration in erythrocytes and in plasma was measured according to a commonly used method.
Results
SOD, GSH-Px, and CAT activity were similar, but plasma and erythrocyte MDA concentrations were significantly higher in CKD patients before ESA treatment in comparison to the control group. SOD, GSH-Px, and CAT activity was significantly higher, but plasma and erythrocyte MDA concentrations were significantly lower, in CKD patients after ESA treatment in comparison to these patients before treatment. We did not find a significant correlation between Hb concentration and SOD, GSH-Px, and CAT activity and plasma, as well as erythrocyte MDA concentrations. Analysis of all investigated groups showed a significant negative correlation between Hb concentration and plasma MDA concentration.
Conclusions
Our results suggest that treatment of anemia with methoxy polyethylene glycol-epoetin beta may inhibit oxidative stress in predialysis patients with CKD by enhancing the antioxidant defense system and reducing ROS production.

Keywords: Erythrocytes - enzymology, Catalase - blood, Erythropoietin - pharmacology, Glutathione Peroxidase - blood, Hematinics - pharmacology, Injections, Subcutaneous, Malondialdehyde - metabolism, Oxidative Stress - drug effects, Polyethylene Glycols - pharmacology, Reactive Oxygen Species - metabolism, Renal Insufficiency, Chronic - metabolism, Superoxide Dismutase - blood

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Medical Science Monitor eISSN: 1643-3750