28 November 2015 : Clinical Research
Elevated Plasma P-Selectin Autoantibodies in Primary Sjögren Syndrome Patients with ThrombocytopeniaYa-Hui HuBCDEF, Peng-Fei ZhouBCDEF, Guang-Feng LongBCDEF, Xin TianBCDEF, Yu-Fan GuoBCDEF, Ai-Ming PangBCDEF, Ran DiBCDEF, Yan-Na ShenBCDEF, Yun-De LiuBCDEF, Yu-Jie CuiA
Med Sci Monit 2015; 21:3690-3695
BACKGROUND: Primary Sjögren’s syndrome (pSS) is one of the most common chronic systemic autoimmune diseases, and thrombocytopenia is one of the hematological manifestations of pSS. When platelet and endothelial cells are activated, P-selectin is expressed on the cell surface. This study aimed to investigate the role of P-selectin autoantibodies in the pathogenesis of thrombocytopenia in pSS.
MATERIAL AND METHODS: P-selectin autoantibodies were measured by enzyme-linked immunosorbent assay (ELISA) in 38 pSS patients without thrombocytopenia and 32 pSS patients with thrombocytopenia, 32 idiopathic thrombocytopenic purpura (ITP) patients, and 35 healthy controls.
RESULTS: The plasma P-selectin autoantibodies (A490) in ITP patients and pSS patients with/without thrombocytopenia were significantly higher than those in healthy controls, but there were no significant differences between ITP patients and pSS patients with thrombocytopenia. The positive rate of P-selectin autoantibodies in pSS patients with thrombocytopenia was significantly higher than that in ITP patients. The platelet count was lower in P-selectin autoantibodies-positive patients, while among pSS patients with thrombocytopenia, the platelet count was lower in P-selectin autoantibodies-positive patients than in P-selectin autoantibodies-negative patients. In ITP patients and pSS patients with thrombocytopenia, the platelet count was lower in P-selectin autoantibodies-positive patients.
CONCLUSIONS: Elevated plasma P-selectin autoantibodies may play a role in the pathogenesis of thrombocytopenia in pSS patients.
Keywords: Autoantibodies - immunology, Adolescent, Blood Platelets - immunology, Enzyme-Linked Immunosorbent Assay, P-Selectin - immunology, Platelet Count, Sjogren's Syndrome - immunology, Thrombocytopenia - immunology
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