Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 September 2017 : Clinical Research

[Retracted: 07 Mar 2019] Mechanisms of Action of MicroRNAs in Infantile Hemangioma Tissue and Vascular Endothelial Cells in Different Periods

Junjiang Chen1ABC, Chen Li2ABC, Yuqiang Li2D, Yu Wang2AEFG*

DOI: 10.12659/MSM.902374

Med Sci Monit 2017; 23:4214-4224

The article is withdrawn by the authors request


BACKGROUND: The aim of this study was to investigate the developmental mechanisms of infantile hemangioma (IH) from the microRNA level.

MATERIAL AND METHODS: A total of 63 biological specimens of IH were obtained from the First Affiliated Hospital of Jinzhou Medical University and we assessed related miRNAs. Magnetic bead sorting, endocytosis test, canalization assay, and immunofluorescence detection were performed. The IH-derived cells were transfected with related factors and then we assessed the apoptosis and invasion.

RESULTS: The contents of MiR-455, miR-206, and miR-29a in the proliferative period group (PP) were lower than in the complete regression period group (CR) (P<0.05), and the content of miR-29a in the regression period group (RP) was lower than in the group CR (P<0.05). The post-sorting proliferation capacity was faster than in human umbilical vein endothelial cells, and IH-derived vascular endothelial cells (VECs) exhibited faster canalization ability. The cells transfected with miR-29a exhibited obvious apoptosis 48 h later, the cells transfected with miR-206 exhibited significantly reduced proliferation capacity as well as apoptosis 48 h later, and the invasion capacity was decreased 24 h after transfection.

CONCLUSIONS: miR-29a, miR-206, and miR-455 are differently expressed in different periods of IH, and may participate in regulating multiple functions during the progression of IH.

Keywords: Retracted Publication

Retraction note

Med Sci Monit 2019; 25:1759-1759     https://medscimonit.com/abstract/index/idArt/915959
  • Download PDF
  • Order reprints
  • Export Article
  • Related articles
  • Share by email
  • Metrics

784 0

Add Comment 0 Comments
Related Articles Metrics Order reprints Share article Share by email


01 July 2024 : Editorial  

Editorial: The Global Threats of Increasing Antimicrobial Resistance Require New Approaches to Drug Development, Including Molecular Antimicrobial Adjuvants

Dinah V. Parums

DOI: 10.12659/MSM.945583

Med Sci Monit 2024; 30:e945583


In Press

Clinical Research  

Cost-Effectiveness Analysis of Hepatic Arterial Chemotherapy for Advanced Hepatocellular Carcinoma in China...

Med Sci Monit In Press; DOI: 10.12659/MSM.944526  


Clinical Research  

Comparative Analysis of Antihypertensive and Anticonvulsant Regimens in Managing Pre-eclampsia and Eclampsi...

Med Sci Monit In Press; DOI: 10.12659/MSM.944985  

Clinical Research  

Reduced Radial Artery Occlusion in Transradial Cerebral Angiography: Key Predictive Factors and Preventive ...

Med Sci Monit In Press; DOI: 10.12659/MSM.944297  

Database Analysis  

Enhanced Outcomes in Femoral Subtrochanteric Fractures Using Long INTERTAN Nails with Titanium Cable Cercla...

Med Sci Monit In Press; DOI: 10.12659/MSM.944383  

Most Viewed Current Articles

17 Jan 2024 : Review article   4,116,598

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research   1,594,331

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research   691,000

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial   50,822

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750