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20 August 2017 : Clinical Research

[Retracted: 26 Mar 2018] Seropositivity and Titers of Anti-Smooth Muscle Actin Antibody Are Associated with Relapse of Type 1 Autoimmune Hepatitis

Taro Shibuki1ABCDEF, Taiga Otsuka2BEF, Hiroshi Isoda3E, Norimasa Araki3E, Yoshihito Kubotsu3E, Yasunori Kawaguchi4B, Shunya Nakashita4E, Wataru Yoshioka4E, Seiji Kawazoe4E, Hiroaki Kawasoe1E, Yasushi Ide5E, Toshihiko Mizuta1ACDEF*, Saga Study Group of Liver Diseases (SASLD)AD

DOI: 10.12659/MSM.902576

Med Sci Monit 2017; 23:4028-4033

This paper is being retracted upon notification from Saga University IRB of the lack of prior approval for the use of their patient data. Reference: Seropositivity and Titers of Anti-Smooth Muscle Actin Antibody Are Associated with Relapse of Type 1 Autoimmune Hepatitis Taro Shibuki, Taiga Otsuka, Hiroshi Isoda, Norimasa Araki, Yoshihito Kubotsu, Yasunori Kawaguchi, Shunya Nakashita, Wataru Yoshioka, Seiji Kawazoe, Hiroaki Kawasoe, Yasushi Ide, Toshihiko Mizuta, Saga Study Group of Liver Diseases (SASLD) Med Sci Monit 2017;23: 4028-4033 10.12659/MSM.902576

Abstract

BACKGROUND: It is important to avoid relapse in autoimmune hepatitis (AIH) because repeated multiple relapses have been associated with a worse prognosis. However, risk factors for relapse before initiation of treatment are not fully understood. The aim of this study was to find predictive markers for relapse of type 1 AIH.

MATERIAL AND METHODS: We reviewed the records of 53 patients diagnosed with type 1 AIH based on the revised scoring system proposed by the International Autoimmune Hepatitis Group (IAIHG) between 2009 and 2014 at 4 hospitals belonging to the Saga Study Group of Liver Diseases (SASLD). We analyzed the differences in background characteristics between patients with or without relapse.

RESULTS: All patients achieved remission after treatment, and 9 (17%) subsequently relapsed. The relapsed patients were significantly younger and had a higher positive rate of anti-smooth muscle antibody (ASMA) than the non-relapsed patients (100% vs. 25%, P=0.0012). Moreover, relapse rate increased with titer of ASMA, while titer of antinuclear antibody was not associated with relapse rate.

CONCLUSIONS: ASMA is a useful predictive marker for relapse of type 1 AIH during or after withdrawal of medical therapy. More careful attention should be paid to immunosuppressive therapy in patients with high titers of ASMA.

Keywords: Autoantibodies, Hepatitis, Autoimmune, Recurrence

Retraction note

Med Sci Monit 2018; 24: 1768-1768     https://medscimonit.com/abstract/index/idArt/910003
 
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