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05 August 2017 : Laboratory Research  

Role of Interleukin-6 and Its Receptor in Endometriosis

Shihui Li1BCDEF, Xiaoxia Fu1BCD, Tingting Wu2CE, Liwei Yang1ABDE, Changchang Hu1EF, RuiJin Wu1ACE*

DOI: 10.12659/MSM.905226

Med Sci Monit 2017; 23:3801-3807

Abstract

BACKGROUND: Studies have shown that the concentration of interleukin (IL)-6 in peritoneal fluid is increased in patients with endometriosis; however, whether the disorders involving IL-6 contribute to the development of endometriosis is still unclear. In the present study, we evaluated the potential role of IL-6 and IL-6 receptor (IL-6R) in the pathogenesis of endometriosis.

MATERIAL AND METHODS: We examined activated macrophages and the expression of membrane-binding receptor (mIL-6R) in peritoneal fluid using flow cytometry. The levels of IL-6 and the IL-6 soluble receptor (sIL-6R) in peritoneal fluid and plasma in patients with endometriosis was measured by an enzyme-linked immunosorbent assay.

RESULTS: Activated macrophages and mIL-6R in peritoneal fluid were increased in patients with endometriosis. IL-6 and sIL-6R in peritoneal fluid were also increased in patients with endometriosis; however, there was an increase in plasma IL-6 and a decrease in plasma sIL-6R. The endometriosis group was categorized into 2 groups according to the retrospective American Fertility Society Score (r-AFS): group A and group B. Peritoneal fluid sIL-6R in endometriosis group B was significantly higher than in endometriosis group A and the control group.

CONCLUSIONS: Disorders involving IL-6 and IL-6R are correlated with the etiology of endometriosis. An increase in sIL-6R in peritoneal fluid promotes the development of endometriosis by enhancing the bioactivity of IL-6.

Keywords: Endometriosis, Gynecology, Interleukin-6, Macrophages

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750