01 December 2018 : Laboratory Research
[Retracted: 06 Aug 2021] Long Noncoding RNA Plasmacytoma Variant Translocation 1 (PVT1) Promotes Colon Cancer Progression via Endogenous Sponging miR-26b
Rui Zhang1ABF, Jibin Li1BCD, Xiaofei Yan1ABC, Keer Jin2BD, Wenya Li1ABD, Xin Liu1DE, Jianfeng Zhao1CF, Wen Shang1CD, Yefu Liu3BDFG*DOI: 10.12659/MSM.910955
Med Sci Monit 2018; 24: LBR8685-8692
Abstract
BACKGROUND: Recently, long noncoding RNAs (lncRNAs) have received wide attention in the area of tumor progression. Dysregulation of lncRNAs has been shown to participated in colon cancer, a known malignant tumor. This study aimed to identify the way lncRNA PVT1 affects the progression of colon cancer.
MATERIAL AND METHODS: Both human colon cancer tissues and 30 paired adjacent normal tissue samples, as well as the colon cancer cells, were collected. Then quantitative real-time (qRT-PCR) was performed to detect the expression of lncRNA PVT1 and miR-26b. Furthermore, the role of PVT1 was determined by function assays such as cell proliferation assay, invasion assay, and wound healing assay. The mechanism was studied using western blot assay and luciferase assay.
RESULTS: We demonstrate that the expression of PVT1 was significantly higher in tumor tissue compared with the adjacent normal tissue with a lower expression of miR-26b. Moreover, PVT1 promoted tumor growth, migration, and invasion in vitro. In addition, further experiments revealed that miR-26b was a direct target of PVT1 and could inhibit cell migration, invasion, and proliferation in colon cancer.
CONCLUSIONS: Our results suggest that PVT1 could promote metastasis and proliferation of colon cancer via endogenous sponging and inhibiting the expression of miR-26b, which may highlight the significance of lncRNA PVT1 in colon cancer tumorigenesis.
Keywords: Retracted Publication
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