27 December 2018 : Clinical Research
Prognostic Value of Hemoglobin A1c Levels in Postmenopausal Diabetic Patients Undergoing Percutaneous Coronary Intervention (PCI) for Acute Coronary Syndrome
Yi Lao1BC, Li Feng1BC, Yong Yuan1AG*, Jin Zhang1CDE, Xuansheng Huang1EF, Mingxing Li1DF, Zidi Wu1DEDOI: 10.12659/MSM.912108
Med Sci Monit 2018; 24: CLR9399-9405
Abstract
BACKGROUND: The purpose of our study was to analyze the clinical value of glycosylated hemoglobin Alc (HbA1c) levels in postmenopausal women with acute coronary syndrome (ACS) and diabetes following percutaneous coronary intervention (PCI).
MATERIAL AND METHODS: A total of 173 consecutive postmenopausal patients with comorbid diabetes underwent PCI for primary ACS were enrolled in this study. Serum HbA1c levels were measured prior to PCI, and baseline clinical characteristics of all patients were collected. All patients were followed up at regular intervals for major adverse cardiovascular events (MACEs) during the first year after PCI. MACEs included cardiac death, non-fatal myocardial infarction, and target vessel revascularization (TVR).
RESULTS: At the endpoint of this study, 29 (16.8%) patients out of all 173 patients had MACEs. According to the effect of glycemic control (as indicated by HbA1c levels), all patients were stratified into a well-controlled group (HbA1c ≤7.0%, N=72) and a poorly-controlled group (HbA1c >7.0%, N=101). The incidence rate of MACEs and TVR in poorly-controlled diabetics was prominently higher than that in well-controlled diabetics (10.8% vs. 21.8%, p=0.04). In multivariable COX regression analysis, after adjustment for potential confounders, HbA1c ≥7.0% remained an independent risk predictor of MACE (HR, 2.17; 95%CI, 1.13–5.65; p<0.01).
CONCLUSIONS: In postmenopausal ACS patients with comorbid diabetes, a high level of HbA1c is associated with a higher MACE rate after PCI, which is mainly driven by a higher rate of TVR.
Keywords: acute coronary syndrome, Diabetes Mellitus, Hemoglobin A, Glycosylated, percutaneous coronary intervention, Postmenopause
Editorial
01 December 2024 : Editorial
Editorial: The 2024 Revision of the Declaration of Helsinki and its Continued Role as a Code of Ethics to Guide Medical ResearchDOI: 10.12659/MSM.947428
Med Sci Monit 2024; 30:e947428
In Press
Clinical Research
Evaluating Lipiodol Efficacy in Proximal Tubal Occlusion Treatment: Single-Center Experience and Literature...Med Sci Monit In Press; DOI: 10.12659/MSM.946266
Review article
Impact of Traditional Chinese Medicine Antioxidants on Oxidative Stress and Drug-Induced Liver Injury: A Re...Med Sci Monit In Press; DOI: 10.12659/MSM.945147
Meta-Analysis
Reliability of Extraoral Scanners in Capturing 3D Geometry for Dental Prostheses: A Systematic ReviewMed Sci Monit In Press; DOI: 10.12659/MSM.946470
Review article
Skin Barrier Dysfunction in Acne Vulgaris: Pathogenesis and Therapeutic ApproachesMed Sci Monit In Press; DOI: 10.12659/MSM.945336
Most Viewed Current Articles
17 Jan 2024 : Review article 6,957,034
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research 1,969,335
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research 697,010
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
07 Jan 2022 : Meta-Analysis 263,050
Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...DOI :10.12659/MSM.935074
Med Sci Monit 2022; 28:e935074