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22 January 2019 : Clinical Research  

Is Sensorineural Hearing Loss Related to Chronic Rhinosinusitis Caused by Outer Hair Cell Injury?

Xi Lin1ABCDEF*, Xin Shan1BE, Shaolian Lin1B, Bo Shu1B, Yingge Wang1C, Wenhui Xiao1E

DOI: 10.12659/MSM.912382

Med Sci Monit 2019; 25:627-636


BACKGROUND: Sensorineural hearing loss is caused by defects in the inner ear. In the present study, associations between chronic rhinosinusitis, outer hair cell injury, and sensorineural hearing loss were investigated.

MATERIAL AND METHODS: A total of 103 patients who met the inclusion criteria were recruited and allocated into a chronic rhinosinusitis group (n=82) and a simple deviated nasal septum group (n=21). Degree and type of hearing loss, including distortion product otoacoustic emissions, were used to assess the status of cochlear outer hair cells.

RESULTS: The rate of hearing loss in the simple deviated nasal septum group was significantly lower than in the chronic rhinosinusitis group (4.76%, 1/21 vs. 24.39%, 20/82, P<0.05), among which 15 chronic rhinosinusitis patients (75%, 15/20) had hearing loss in the high frequency range. Acoustic stapedial reflexes were elicited in all patients of the 2 groups, while positive Metz was found in 3 chronic rhinosinusitis patients (15%, 3/20). The pass rate of distortion product otoacoustic emissions (DPOAEs) for chronic rhinosinusitis patients was significantly lower than in simple deviated nasal septum patients (88.10% vs. 70.73%, P<0.05). Moreover, the signal-to-noise ratio of DPOAE test results at 704 Hz, 3991 Hz, and 5649 Hz in the chronic rhinosinusitis group were significantly lower than in the simple deviated nasal septum group (P<0.05). Logistic regression analysis revealed a correlation between severity of chronic rhinosinusitis and sensorineural hearing loss (OR=1.39, P<0.05).

CONCLUSIONS: Outer hair cell injury and sensorineural hearing loss may have a common cause in chronic rhinosinusitis patients.

Keywords: Hair Cells, Auditory, Outer, Hearing Loss, Sensorineural, Otoacoustic Emissions, Spontaneous, Adolescent, Audiometry, Pure-Tone, Auditory Threshold, Chronic Disease, Hearing Loss, Nasal Septum, Sinusitis, young adult

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750