02 December 2003
Age related natural antiviral non-specific immunity of human leukocytes
Katarzyna Rybka, Beata Orzechowska, Iwona Siemieniec, Jerzy Leszek, Ewa Zaczyńska, Jarosław Pająk, Zofia Błach-OlszewskaMed Sci Monit 2003; 9(12): BR413-417 :: ID: 13420
Abstract
Background:The purpose of our study was to examine the dependence of innate antiviral immunity on age and sex in human leukocytes.Material/Methods:Innate antiviral immunity was measured by using the direct method of infection of leukocytes with vesicular stomatitis virus (VSV), which was selected as the indicatory virus for detection of immunity. The lack of VSV replication by infected leukocytes (0–1 log TCID50) was taken as an indicator for complete immunity; a low level of VSV replication (2–3 log) for partial immunity; and a high VSV titer (4 or more log) for the no or very low immunity.Results:The kinetics of VSV replication was studied in leukocytes isolated from 127 individuals ranging in a age from 0 to 89 years. Individual differentiation in the kinetics of VSV replication indicated differing degrees of innate immunity even in newborns. Age-related differences in natural immunity were observed: low immunity in newborns, highest in the age group 31–40, and reduced in the age group >60. Sex dependent innate immunity was shown in the group of aged persons, as innate immunity was higher in women than in men.Conclusions:Innate immunity of leukocytes develops to age 30–40, after which immunity is gradually reduced. Sex dependence was observed only in the group of elderly persons, where women expressed higher immunity; this is probably a reason for their statistically greater longevity.
Keywords: Aged, 80 and over, Aging - immunology, Fetal Blood - cytology, Fetal Blood - immunology, Immunity, Natural, Infant, Newborn, Leukocytes - immunology, Pregnancy, Sex Characteristics, Vesicular stomatitis-Indiana virus - immunology
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
12 Mar 2024 : Clinical Research
Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe PsoriasisMed Sci Monit In Press; DOI: 10.12659/MSM.943360
14 Mar 2024 : Clinical Research
Renal Dysfunction Increases Risk of Adverse Cardiovascular Events in 5-Year Follow-Up Study of Intermediate...Med Sci Monit In Press; DOI: 10.12659/MSM.943956
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952