20 May 2003
Follow-up of patients with chronic hepatitis C who discontinued antiviral treatment because of side effects
W. Kryczka, D. Zarębska-Michaluk, K. PaluchMed Sci Monit 2003; 9(2): 10-0 :: ID: 15239
Abstract
Background:Premature withdrawal from antiviral therapy due to adverse events was required in 10%to 14%of chronic hepatitis C (CHC)patients (Fried MW:Hepatology 2002;36: S237-S244).There is a few data about subsequent history of them.The aim of our study was to evaluate the outcome of HCV infection among patients for whom the antiviral therapy had been withdrawn due to severe adverse effects. Material/Methods: Of the all 196 CHC patients treated with interferon alpha (alone or with ribavirin),26 (F/M:17/9;age: 23 –66,median:43.5yrs)had required cessation of therapy (3 to 34,median 16 weeks)because of adverse reactions.There were:angina pectoris (5),autoimmune hepatitis (1), tuberculosis (1),pyonephrosis (1),thrombocytopenia (3), ketoacidotic diabetes (1),thyrotoxicosis (10),manic psychosis (3)and retinal detachment (1).All patients were followed up to 12 –60 (median 24)months after cessation of therapy (CT).Results:In all patients,the adverse effects had been withdrawn during follow-up after CT.At the moment of CT,10 patients showed complete (biochemical and virological)response but only 4 of them maintained sustained response (SR)up to end of follow-up.Of 16 non-responders at CT,3 patients spontaneously cleared HCV and normalised ALT during follow-up.Those 7 patients with SR (4F/3M)were younger and had been treated longer than the others.Conclusions:About a quarter of patients with CHC who discontinued antiviral treatment because of side effects eliminated HCV either at CT or during follow-up.
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Database Analysis
Risk Factors of Age-Related Macular Degeneration in a Population-Based Study: Results from SHIP-TREND-1 (St...Med Sci Monit In Press; DOI: 10.12659/MSM.943140
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952