01 January 2002
Level of antithrombin III, protein C, protein S and other selected parametersof coagulation and fibrinolysis in the blood of the patients with recurrent deep venous thrombosis.
Arkadiusz Jawień, Piort Jurkowski, Marek Ciecierski, Maria Kotschy, Andrzej SwiatkiewiczMed Sci Monit 2002; 8(4): CR263-268 :: ID: 420870
Abstract
BACKGROUND: Thrombophilia is caused mainly by disturbances of hemostasisinvolving excessive coagulation system activation, reduction of anticoagulation system (antithrombinIII, protein C, protein S, RAPC) or fibrinolytic activity. MATERIAL/METHODS: In 34 young patients (aged2 incidents) the activity of antithrombin III, proteinC, S, platelet count, adhesion and aggregation, APTT, stipven-kephalin, prothrombin time and INR wereinvestigated. Fibrinogen, factor XIII, ELT, FDP, Ag t-PA levels, antigen concentration and PAI-1 activitywere determined. Patients with idiopathic DVT, after elimination of most important thromboembolism riskfactors, were qualified for the study. DVT was confirmed in all patients by phlebography, plethysmographyand ultrasonography. Results were compared with a group of 54 healthy controls. RESULTS: In almost 50%of patients with recurrent DVT (15/34) decrease of at least one plasma coagulation inhibitor (AT III,PC, PS) level was observed. In the patient group (with AT III and/or PC and/or PS decrease) statisticallysignificant reduction of kaolin-kephalin time in comparison with controls was observed (α<0. 01). Analysis of fibrinolysis system demonstrated significant factor XIII level decrease (to 58.3%), fibrinogen level increase, ELT prolongation, and fibrinogen and fibrin degradation product increase in comparison with controls. The patients demonstrated 3-fold higher t-PA antigen level (13.1 ng/ml, α<0. 0001) and over 3-fold higher PAI-1 activity (26.7 AU/ml, α<0. 001) than healthy controls.
Conclusions: Reduced antithrombin III, protein C, protein S activity and excessive activation of the coagulation system with secondary fibrinolytic activity increase were found in patients with recurrent DVT.
Keywords: Antithrombin III, Blood Coagulation Tests, Fibrin Fibrinogen Degradation Products, Fibrinolysis, Phlebography, Plasminogen Activator Inhibitor 1, Platelet Function Tests, Plethysmography, Protein C, Protein S, Recurrence, Risk Factors, Thrombophilia, Tissue Plasminogen Activator, Venous Thrombosis
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
12 Mar 2024 : Clinical Research
Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe PsoriasisMed Sci Monit In Press; DOI: 10.12659/MSM.943360
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952