22 February 2002
Tonal nitric oxide and health: anti-bacterial and -viral actions and implications for HIV
Patrick Cadet, Kirk Mantione, Danielle Benz, Wei Zhu, George StefanoMed Sci Monit 2002; 8(2): RA27-31 :: ID: 420921
Abstract
Nitric oxide has been shown to have important physiological regulatoryroles, i. e, vasodilation, neurotransmitter release, etc. Now, we review its role as an antibacterialand antiviral agent. Nitric oxide has also been identified as an important factor in the developmentof non-specific immunity. And accordingly, nitric oxide synthase (NOS), the catalytic enzyme producingnitric oxide, is a key element in the protective activities of nitric oxide. The expression of inducible(i) NOS is regulated by cytokines. iNOS-derived nitric oxide was found to contribute to both early andlate phases of antibacterial activity. Enzymes, such as proteases (reverse transciptases, and ribonucleotidereductase, etc.) containing cysteine residues, appear to be targets for nitric oxide nitrosylation, aswell as viral-encoded transcription factors that are involved in viral replication. It would appear thatthis multifunctional signaling molecule is not only involved with signaling between cells, it also appearsto maintain the immediate environment free of microbial agents.
Keywords: Anti-Infective Agents, Antiviral Agents, HIV, Nitric Oxide, Research Support, Non-U.S. Gov, Research Support, U.S. Gov
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
12 Mar 2024 : Clinical Research
Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe PsoriasisMed Sci Monit In Press; DOI: 10.12659/MSM.943360
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952