01 January 2001
Connective tissue skeleton in the normal left ventricle and in hypertensiveleft ventricular hypertrophy and chronic chagasic myocarditis.
Marcos A RossiMed Sci Monit 2001; 7(4): RA820-832 :: ID: 421064
Abstract
Pictures certainly are worth a thousand words in the case of the structureof the connective tissue skeleton of normal and diseased myocardium. This report reviews the connectivetissue matrix of the normal human myocardial tissue and the pathological myocardial fibrosis in leftventricular hypertrophy due to chronic arterial hypertension in humans and in human chronic chagasicmyocarditis. The myocardial connective tissue matrix was studied employing a cell-maceration method thatremoves the myocardial tissue non-fibrous elements, and leaves behind a non-collapsed matrix, thus allowinga better three-dimensional view. Such information extends our knowledge of the expression of interstitialmyocardial fibrous tissue in normal hearts and in hypertensive left ventricular hypertrophy and chronicchagasic myocarditis. The progressive accumulation of interstitial collagen fibers in both chronic cardiacdiseases may be expected to decrease myocardial compliance and disrupt synchronous contractions of theventricles during systole, contributing to a spectrum of ventricular dysfunction that involve eitherthe diastolic or systolic phase of the cardiac cycle or both. In hypertensive heart disease myocardialfibrosis can be also implicated in the genesis of ventricular dysrhythmias, possible causes of suddendeath among chronic hypertensive patients. Regarding chronic chagasic myocarditis, myocardial fibrosisis probably implicated in the genesis of malignant ventricular tachyarrhythmias (ventricular tachycardiaand ventricular fibrillation), major causes of sudden death among patients with chronic Chagas' heartdisease. The collagen distribution could interfere on the electrical properties of the myocardium. Fibrosiscan block the cardiac impulse that may recycle (re-entry) through an alternative route and could slowconduction. In addition, the thick collagenous septa encompassing muscle fiber bundles could interferewith lateral impulse conduction, which would favor re-entry. Moreover, the methodology used is a usefultool to study the spatial organization of the collagen fibrils of the myocardium under normal and pathologicalconditions.
Keywords: Myocardium, connective tissue matrix, left ventricular hypertrophy, hypertensive heart disease,, left ventricular hypertrophy, chronic chagasic myocarditis, cell-maceration
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
12 Mar 2024 : Clinical Research
Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe PsoriasisMed Sci Monit In Press; DOI: 10.12659/MSM.943360
14 Mar 2024 : Clinical Research
Renal Dysfunction Increases Risk of Adverse Cardiovascular Events in 5-Year Follow-Up Study of Intermediate...Med Sci Monit In Press; DOI: 10.12659/MSM.943956
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952